High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C.

High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Research Abstract Details 

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High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Abstract Text:

Yasunori Kawaguchi,Toshihiko Mizuta,Kazuhiro Takahashi,Shinji Iwane,Keisuke Ario,Hiroaki Kawasoe,Kazuhiro Hamaoka,Yuichiro Eguchi,Tsutomu Yasutake,Hironao Shigematsu,Seiji Kawazoe,Noriko Fukushima,Iwata Ozaki,Kazuma Fujimoto,

Aim: In combination therapy using interferon (IFN) and ribavirin for chronic hepatitis C, reduced doses should be used due to ribavirin-induced hemolytic anemia. The present study aimed to elucidate whether high-dose vitamins E and C supplementation attenuated ribavirin-induced hemolytic anemia. Methods: Twenty-one consecutive patients with chronic hepatitis C were enrolled in this study between July 2003 and December 2004, and received high-dose vitamins E (2000 mg) and C (2000 mg) supplementation, daily, in addition to IFN alfa-2b and ribavirin combination therapy (vitamins E/C group). Twenty-one sex- and age-matched patients who received a standard regimen of IFN alfa-2b and ribavirin for chronic hepatitis C between January 2001 and June 2003 were evaluated as the control group. Results: Decrease in hemoglobin level was significantly prevented in the vitamins E and C group compared to that in the control group (P = 0.029). Three (14.3%) patients in the control group discontinued treatment because of anemia, while no treated patient dropped out of the study due to anemia. Sustained virological response was not significantly different between the two groups. Conclusion: High-dose vitamins E and C supplementation prevented ribavirin-induced hemolytic anemia during combination therapy with ribavirin and IFN alfa-2b in patients with chronic hepatitis C.

High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Publishing Authors By Initials

Y Kawaguchi,T Mizuta,K Takahashi,S Iwane,K Ario,H Kawasoe,K Hamaoka,Y Eguchi,T Yasutake,H Shigematsu,S Kawazoe,N Fukushima,I Ozaki,K Fujimoto,

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High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 37

Page Numbers: 317-24

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ISSN: 1386-6346

DAY: 19

MONTH: May

YEAR: 2007

High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Information

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LANGUAGE: eng

NlmUniqueID: 9711801

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Grant and Affiliation Information for High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C.

AFFILIATION: Department of Internal Medicine, Saga Medical School, Saga, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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