High-dose methotrexate in combination chemotherapy for small cell lung cancer.

High-dose methotrexate in combination chemotherapy for small cell lung cancer. Research Abstract Details 

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High-dose methotrexate in combination chemotherapy for small cell lung cancer. Abstract Text:

F A Greco,K R Hande,R L Richardson,R K Oldham,

High-dose methotrexate and Leucovorin (calcium folinate) rescue was evaluated as induction chemotherapy in combination with cyclophosphamide, doxorubicin, and vincristine in 21 patients with extensive-stage small cell lung cancer. Nine (42%) of 21 had a complete remission. The median duration of remission has been short (5 months), and attempts are now under way to improve consolidation chemotherapy. In general, the degree of myelotoxicity was not increased by the high-dose methotrexate, although the antitumor activity of the combination appears enhanced. Attempts at further increasing the intensity of this regimen or comparative trials with other therapy appears warranted.

High-dose methotrexate in combination chemotherapy for small cell lung cancer. Publishing Authors By Initials

FA Greco,KR Hande,RL Richardson,RK Oldham,

For similar persons: age groups: adult: middle aged research abstracts see: persons: age groups: adult: middle aged research

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High-dose methotrexate in combination chemotherapy for small cell lung cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 74

Page Numbers: 50-5

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1980

High-dose methotrexate in combination chemotherapy for small cell lung cancer. Information

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LANGUAGE: eng

NlmUniqueID: 44671

High-dose methotrexate in combination chemotherapy for small cell lung cancer. Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: High-dose methotrexate in combination chemotherapy for small cell lung cancer. Information

Substance Name: Methotrexate

Registry Number: 59-05-2

Grant and Affiliation Information for High-dose methotrexate in combination chemotherapy for small cell lung cancer.

AFFILIATION:

Country: GERMANY, WEST

AGENCY: United States NCRR

GRANT: 5M01 RR-95

ACRONYM: RR

MEDLINETA: Recent Results Cancer Res

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