High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain.

High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Abstract Text:

Abstract Background: Oxidative stress plays an important role in atherosclerosis. Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme that inhibits low-density lipoprotein (LDL) oxidation and may play a protective role against coronary heart disease. The aim of this study was to analyze the relationship between HDL-cholesterol (HDL-C) and PON1 in a Spanish prepubertal population with high plasma HDL-C levels. Methods: The study population included 1266 children between the ages of 6 and 8 years. Serum PON1 activity was measured by the hydrolysis of paraoxon. PON1 192Q/R and PON1 55L/M polymorphisms were analyzed by PCR and restriction analysis. Results: The prevalence of the less common PON1 192R and PON 55M alleles in this population was 30% and 38%, respectively. No significant correlations between serum PON1 activity and lipid profile were observed. Multiple linear regression analysis showed that the PON1 192Q/R polymorphism accounts for 69% of PON1 activity in the children in the study, with the PON1 55L/M polymorphism accounting for an additional 5% of this variation in boys, and for an additional 3% together with HDL-C concentration in girls. Conclusions: PON1 192Q/R polymorphism is the main determinant of PON1 activity in the prepubertal population in this study, accounting for around 70% of serum PON1 activity. HDL-C concentration has a small contribution to serum PON1 activity in girls. Clin Chem Lab Med 2008;46:809-13.

High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical chemistry and laboratory medicine : CCLM

VOLUME: 46

Page Numbers: 809-13

Journal Abbreviation: Clin. Chem. Lab. Med.

ISSN: 1434-6621

DAY: 8

MONTH: 07

YEAR: 2008

High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9806306

High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain.

AFFILIATION: 1Lipid Laboratory, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Chem Lab Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

High-density lipoprotein cholesterol and paraoxonase 1 PON1 genetics and serum PON1 activity in prepubertal children in Spain Related Publications

• Anthrone reaction in estimation of carbohydrates.
• High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain.
• Hormone levels in 12- to 15-year-old boys and girls in Spain and their relationship with anthropometric variables.
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Pathological anatomy of alloxan diabetes.]
• [Phenomenon of toxialepsia.]
• [Role of the kidney in experimental diabetes.]
• [The clinical diagnosis of acute rheumatism.]