High-density lipoprotein and the risk of recurrent venous thromboembolism.

High-density lipoprotein and the risk of recurrent venous thromboembolism. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

High-density lipoprotein and the risk of recurrent venous thromboembolism. Abstract Text:

Sabine Eichinger,Natalie M Pecheniuk,Gregor Hron,Hiroshi Deguchi,Michael Schemper,Paul A Kyrle,John H Griffin,

BACKGROUND: High-density lipoprotein (HDL) protects against arterial atherothrombosis, but it is unknown whether it protects against recurrent venous thromboembolism. METHODS AND RESULTS: We studied 772 patients after a first spontaneous venous thromboembolism (average follow-up 48 months) and recorded the end point of symptomatic recurrent venous thromboembolism, which developed in 100 of the 772 patients. The relationship between plasma lipoprotein parameters and recurrence was evaluated. Plasma apolipoproteins AI and B were measured by immunoassays for all subjects. Compared with those without recurrence, patients with recurrence had lower mean (+/-SD) levels of apolipoprotein AI (1.12+/-0.22 versus 1.23+/-0.27 mg/mL, P<0.001) but similar apolipoprotein B levels. The relative risk of recurrence was 0.87 (95% CI, 0.80 to 0.94) for each increase of 0.1 mg/mL in plasma apolipoprotein AI. Compared with patients with apolipoprotein AI levels in the lowest tertile (<1.07 mg/mL), the relative risk of recurrence was 0.46 (95% CI, 0.27 to 0.77) for the highest-tertile patients (apolipoprotein AI >1.30 mg/mL) and 0.78 (95% CI, 0.50 to 1.22) for midtertile patients (apolipoprotein AI of 1.07 to 1.30 mg/mL). Using nuclear magnetic resonance, we determined the levels of 10 major lipoprotein subclasses and HDL cholesterol for 71 patients with recurrence and 142 matched patients without recurrence. We found a strong trend for association between recurrence and low levels of HDL particles and HDL cholesterol. CONCLUSIONS: Patients with high levels of apolipoprotein AI and HDL have a decreased risk of recurrent venous thromboembolism.

High-density lipoprotein and the risk of recurrent venous thromboembolism. Publishing Authors By Initials

S Eichinger,NM Pecheniuk,G Hron,H Deguchi,M Schemper,PA Kyrle,JH Griffin,

For similar cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis: venous thrombosis research abstracts see: cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis: venous thrombosis research

PUBMED ID PMID:

MEDLINE DATE:

High-density lipoprotein and the risk of recurrent venous thromboembolism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Circulation

VOLUME: 115

Page Numbers: 1609-14

Journal Abbreviation: Circulation

ISSN: 1524-4539

DAY: 19

MONTH: 03

YEAR: 2007

High-density lipoprotein and the risk of recurrent venous thromboembolism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 147763

High-density lipoprotein and the risk of recurrent venous thromboembolism. Keywords Mesh Terms:

KEYWORDS: Venous Thrombosis

MESH TERMS: epidemiology

Chemical & Substance for Abstract: High-density lipoprotein and the risk of recurrent venous thromboembolism. Information

Substance Name: Lipoproteins, HDL

Registry Number: 0

Grant and Affiliation Information for High-density lipoprotein and the risk of recurrent venous thromboembolism.

AFFILIATION: Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

Country: United States

AGENCY: United States NHLBI

GRANT: HL52246

ACRONYM: HL

MEDLINETA: Circulation

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

High-density lipoprotein and the risk of recurrent venous thromboembolism Related Publications

• A field-sweep/field-lock system for superconducting magnets--Application to high-field EPR.
• Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
• Commercial aspects of bovine embryo transfer.
• Comparison of low versus high tacrolimus levels in kidney transplantation: assessment of efficacy by protocol biopsies.
• Description of depolarization effects in double-quantum solid state nuclear magnetic resonance experiments using multipole-multimode Floquet theory.
• Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.
• Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
• Equine fetal kinetics: Presentation and location.
• Eye movement, vection, and motion sickness with foveal and peripheral vision.
• Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination.
• High-density lipoprotein and the risk of recurrent venous thromboembolism.
• High-frequency dynamic nuclear polarization using mixtures of TEMPO and trityl radicals.
• Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry.
• In situ temperature jump high-frequency dynamic nuclear polarization experiments: enhanced sensitivity in liquid-state NMR spectroscopy.
• Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine.
• Increasing Stimulation Frequency Prolongs Force Output in Healthy Thenar Muscle: 1923: Board #211 10:30 AM- 10:30 AM.
• Interpreting treatment effects when cases are institutionalized after treatment.
• Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.
• Multipole-multimode Floquet theory of rotational resonance width experiments: 13C-13C distance measurements in uniformly labeled solids.
• Natural outcome and ultrasonic identification of equine fetal twins.
• Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
• Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry.
• Proton assisted insensitive nuclei cross polarization.
• Recovery and transfer of equine embryos.
• Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.
• Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide.
• Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance.
• Sustaining knowledge transfer through leadership.
• Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system.
• TOTAPOL: a biradical polarizing agent for dynamic nuclear polarization experiments in aqueous media.