High cut-off point membranes in septic acute renal failure: A systematic review.

High cut-off point membranes in septic acute renal failure: A systematic review. Research Abstract Details 

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High cut-off point membranes in septic acute renal failure: A systematic review. Abstract Text:

M Haase,R Bellomo,S Morger,I Baldwin,N Boyce,M Haase,R Bellomo,S Morger,I Baldwin,N Boyce,

Objectives: To review the literature on the experimental, physiological and clinical effects of blood purification with high cut-off (HCO) point membranes in septic acute renal failure (ARF). Study Design: MEDLINE and PubMed database search combining relevant terms and integrating data from studies on the use of HCO membranes. Setting and Population: Ex vivo studies of endotoxemia, animal studies of bacteremia and clinical studies using HCO membranes in patients with septic ARF. Selection Criteria for Studies: Original data from primary publications. Interventions: HCO membrane-based hemodialysis, hemodiafiltration or hemofiltration. Outcomes: Plasma cytokine clearance, immunological and physiological effects and safety parameters of HCO membranes. Results: HCO membranes effectively remove cytokines from blood. Treatment using HCO membranes has beneficial effects on immune cell function and increases survival in animal models of sepsis. Preliminary clinical studies show that HCO membranes decrease plasma cytokine levels and the need for vasopressor therapy. HCO membrane-based blood purification has now been applied in four pilot randomized controlled studies of 70 patients with septic ARF with no reports of serious adverse effects. Limitations: Because of substantial heterogeneity, no formal quantitative analysis could be performed. Conclusions: The available evidence on HCO blood purification justifies larger randomized controlled trials in patients with septic ARF.

High cut-off point membranes in septic acute renal failure: A systematic review. Publishing Authors By Initials

M Haase,R Bellomo,S Morger,I Baldwin,N Boyce,M Haase,R Bellomo,S Morger,I Baldwin,N Boyce,

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High cut-off point membranes in septic acute renal failure: A systematic review. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The International journal of artificial organs

VOLUME: 30

Page Numbers: 1031-41

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ISSN: 0391-3988

DAY: 18

MONTH: Dec

YEAR: 2007

High cut-off point membranes in septic acute renal failure: A systematic review. Information

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LANGUAGE: eng

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Grant and Affiliation Information for High cut-off point membranes in septic acute renal failure: A systematic review.

AFFILIATION: Intensive Care Unit, Austin Hospital, University of Melbourne - Australia and Department of Nephrology and Intensive Care, Charité University Medicine, Berlin - Germany.

Country: Italy

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MEDLINETA: Int J Artif Organs

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