The concentrations of free D- and L-amino acids were determined in the gastric juice from four groups: patients suffering from early gastric carcinoma with or without Helicobacter pylori infection, and patients without carcinoma but with peptic ulcers, duodenal ulcers or chronic gastritis with or without H. pylori infection. H. pylori is a bacterium associated with gastric inflammation and peptic ulcers and is a risk factor for stomach cancer. The highest D-amino acid ratios (free D-amino acid concentration to the total corresponding free D- and L-amino acid concentration) were 29%, 26%, 18%, 4% and 1% for proline, alanine, serine, aspartate and glutamate, respectively. The gastric juice levels of L-alanine, L-serine, L-proline, L-glutamate and D-alanine in the samples obtained from subjects bearing early gastric carcinoma and H. pylori were significantly higher than in the samples from the other three groups. Except for D-alanine, there was no correlation between the D-amino acid concentrations and presence of carcinoma or H. pylori.
High concentrations of D-amino acids in human gastric juice. Publishing Authors By Initials
High concentrations of D-amino acids in human gastric juice. Journal Published:
PUBLICATION TYPE: Journal Article
Journal: Amino acids
VOLUME: 32
Page Numbers: 137-40
Journal Abbreviation: Amino Acids
ISSN: 0939-4451
DAY: 4
MONTH: 04
YEAR: 2006
High concentrations of D-amino acids in human gastric juice. Information
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LANGUAGE: eng
NlmUniqueID: 9200312
High concentrations of D-amino acids in human gastric juice. Keywords Mesh Terms:
KEYWORDS: Stomach Diseases
MESH TERMS: microbiology
Chemical & Substance for Abstract: High concentrations of D-amino acids in human gastric juice. Information
Substance Name: Amino Acids
Registry Number: 0
Grant and Affiliation Information for High concentrations of D-amino acids in human gastric juice.
AFFILIATION: Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan. nagata@chem.cst.nihon-u.ac.jp
Country: Austria
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MEDLINETA: Amino Acids
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