Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis.

Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Research Abstract Details 

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Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Abstract Text:

Olga Kirillina,Alexander G Bobrov,Jacqueline D Fetherston,Robert D Perry,

In addition to the yersiniabactin (Ybt) siderophore-dependent system, two inorganic iron ABC transport systems of Yersinia pestis, Yfe and Yfu, have been characterized. Here we show that the Yfu system functions in Y. pestis: a Ybt- Yfe- Yfu- mutant exhibited a greater growth defect under iron-deficient conditions than its Ybt- Yfe- parental strain. We also demonstrate that another putative Y. pestis iron uptake system, Yiu, which potentially encodes an outer membrane receptor, YiuR, and an ABC iron transport cassette, YiuABC, is functional. The cloned yiuABC operon restored growth of an enterobactin-deficient mutant Escherichia coli strain, 1017, under iron-chelated conditions. Iron uptake by the Yiu system in Y. pestis was demonstrated only when the Ybt, Yfe, and Yfu systems were mutated. Using a yiuA::lacZ fusion, we show that the yiuABC promoter is repressed by iron through Fur. A mouse model of bubonic plague failed to show a significant role for the Yiu system in the disease process. These results demonstrate that two additional iron transporters are functional in Y. pestis and indicate that there is a hierarchy of iron transporters, with Ybt being most effective and Yiu being the least effective of those systems which have been characterized.

Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Publishing Authors By Initials

O Kirillina,AG Bobrov,JD Fetherston,RD Perry,

For similar bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: yersinia: yersinia pestis research abstracts see: bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: yersinia: yersinia pestis research

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Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Infection and immunity

VOLUME: 74

Page Numbers: 6171-8

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 5

MONTH: 09

YEAR: 2006

Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Keywords Mesh Terms:

KEYWORDS: Yersinia pestis

MESH TERMS: physiology

Chemical & Substance for Abstract: Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Hierarchy of iron uptake systems: Yfu and Yiu are functional in Yersinia pestis.

AFFILIATION: Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40656-0298, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI-33481

ACRONYM: AI

MEDLINETA: Infect Immun

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