Heterogeneous inclusions in neurofilament inclusion disease.

Heterogeneous inclusions in neurofilament inclusion disease. Research Abstract Details 

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Heterogeneous inclusions in neurofilament inclusion disease. Abstract Text:

Hirotake Uchikado,Ang Li,Wen-Lang Lin,Dennis W Dickson,

Neurofilament inclusion disease (NFID) is a rare disease, whose pathogenesis remains to be elucidated. Immunoreactivity of ubiquitin-binding protein p62 has been reported in various neurodegenerative diseases, but it has not been studied in NFID. In this report we show p62 immunoreactivity in neuronal perikaryon of three cases of NFID. We found inclusions in NFID to be heterogenous based on immunoreactivity for alpha-internexin, phosphorylated neurofilament-H, p62 and ubiquitin. Moreover, we showed both p62- and alpha-internexin-immunoreactive inclusions within the perikarya of the same neuron. Electron microscopy findings support the notion that inclusions in NFID are heterogenous. The present study extends the list of proteins that have been identified as components of neuronal inclusions in NFID, and may help account for the pathogenesis of NFID.

Heterogeneous inclusions in neurofilament inclusion disease. Publishing Authors By Initials

H Uchikado,A Li,WL Lin,DW Dickson,

For similar proteins: carrier proteins: rna-binding proteins research abstracts see: proteins: carrier proteins: rna-binding proteins research

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Heterogeneous inclusions in neurofilament inclusion disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropathology : official journal of the Japanese

VOLUME: 26

Page Numbers: 417-21

Journal Abbreviation:

ISSN: 0919-6544

DAY: 3

MONTH: Oct

YEAR: 2006

Heterogeneous inclusions in neurofilament inclusion disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9606526

Heterogeneous inclusions in neurofilament inclusion disease. Keywords Mesh Terms:

KEYWORDS: RNA-Binding Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Heterogeneous inclusions in neurofilament inclusion disease. Information

Substance Name: alpha-internexin

Registry Number: 0

Grant and Affiliation Information for Heterogeneous inclusions in neurofilament inclusion disease.

AFFILIATION: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.

Country: Australia

AGENCY: United States NIA

GRANT: P50-AG16574

ACRONYM: AG

MEDLINETA: Neuropathology

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