[Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit]

[Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit] Research Abstract Details 

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[Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit] Abstract Text:

Yang Li,Jie Ma,Jian-Min Xiao,Nian Liu,Hui-Yan Niu,Zai-Ying Lu,

Experiments were performed to investigate the heterogeneity of the action potential and ion currents in left ventricular myocytes of the rabbit. Myocytes were isolated by enzymatic method. The sub-endocardial (Endo) and sub-epicardium (Epi) tissues were separated from the other region (midmyocardium, M) with a razor. Single cells in each region were obtained by gentle shaking and dispersing in a chamber filled with normal Tyrode's solution. The results showed that the action potential and the ion currents in the three layers were significantly different. M cells had a more pronounced spike-and-dome configuration, with a significantly larger phase 1 magnitude and plateau voltage. Action potential duration (APD) in M cells was longer than that in Epi or Endo cells. I(Ca, L) and I(to) in M cells were higher than those of Epi and Endo. On the contrary, I(K,s) in M cells was the minimum compared with those in the three LV walls. The differences in ion currents may well explain the heterogeneity of action potentials in M layers of the rabbit heart.

[Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit] Publishing Authors By Initials

Y Li,J Ma,JM Xiao,N Liu,HY Niu,ZY Lu,

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[Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 54

Page Numbers: 369-74

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ISSN: 0371-0874

DAY: 25

MONTH: Oct

YEAR: 2002

[Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit] Information

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LANGUAGE: chi

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AFFILIATION: Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. liyang40@hotmail.com

Country: China

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MEDLINETA: Sheng Li Xue Bao

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