Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection.

Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. Research Abstract Details 

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Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. Abstract Text:

OBJECTIVE: We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California. DESIGN: The study was a retrospective cohort analysis. METHODS: We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1-3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry. RESULTS: We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log(10) copies/mL; P=.39) and early infection (4.57 vs. 4.67 log(10) copies/mL; P=.5). Longitudinally, the difference in HIV-1 loads between HSV-2-seropositive and -seronegative men remained close to 0 during the first year of infection. CONCLUSIONS: HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection.

Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. Publishing Authors By Initials

For similar investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research abstracts see: investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research

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Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 1270-7

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 15

MONTH: 03

YEAR: 2007

Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. Information

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LANGUAGE: eng

NlmUniqueID: 413675

Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. Keywords Mesh Terms:

KEYWORDS: Viral Load

MESH TERMS: pathogenicity

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Grant and Affiliation Information for Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection.

AFFILIATION: University of California, San Diego, La Jolla, CA 92103, USA. ecachay@ucsd.edu

Country: United States

AGENCY: United States NIAID

GRANT: AI57167

ACRONYM: AI

MEDLINETA: J Infect Dis

REFSOURCE: J Infect Dis. 2007 May 1;195(9):1242-4

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