Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts.

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Abstract Text:

Roger D Everett,Jill Murray,Anne Orr,Chris M Preston,Roger D Everett,Jill Murray,Anne Orr,Chris M Preston,

Herpes simplex virus type 1 (HSV-1) genomes become associated with structures related to cellular nuclear substructures known as ND10 or promyelocytic leukemia nuclear bodies during the early stages of lytic infection. This paper describes the relationship between HSV-1 genomes and ND10 in human fibroblasts that maintain the viral genomes in a quiescent state. We report that quiescent HSV-1 genomes detected by fluorescence in situ hybridization (FISH) are associated with enlarged ND10-like structures, frequently such that the FISH-defined viral foci are apparently enveloped within a sphere of PML and other ND10 proteins. The number of FISH viral foci in each quiescently infected cell is concordant with the input multiplicity of infection, with each structure containing no more than a small number of viral genomes. A proportion of the enlarged ND10-like foci in quiescently infected cells contain accumulations of the heterochromatin protein HP1 but not other common markers of heterochromatin such as histone H3 di- or trimethylated on lysine residue 9. Many of the virally induced enlarged ND10-like structures also contain concentrations of conjugated ubiquitin. Quiescent infections can be established in cells that are highly depleted for PML. However, during the initial stages of establishment of a quiescent infection in such cells, other ND10 proteins (Sp100, hDaxx, and ATRX) are recruited into virally induced foci that are likely to be associated with HSV-1 genomes. These observations illustrate that the intimate connections between HSV-1 genomes and ND10 that occur during lytic infection also extend to quiescent infections.

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Publishing Authors By Initials

RD Everett,J Murray,A Orr,CM Preston,RD Everett,J Murray,A Orr,CM Preston,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 10991-1004

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 1

MONTH: 08

YEAR: 2007

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts.

AFFILIATION: MRC Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom. r.everett@mrcvu.gla.ac.uk

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts Related Publications

• A brief review of the past, present and future of wood preservation.
• A rare case of multiple accessory breast tissue in the axillae, lower abdomen and vulval areas.
• A study of conformational restraints on reactivity of human PR3-specific autoantibodies (ANCA) facilitated through protein folding manipulations of a new recombinant proteinase 3 protein.
• An unusual case of traumatic diaphragmatic hernia with successful operation.
• DISTANCE OBJECT TEST TYPE FOR CHILDREN.
• Energy expenditure and protein synthesis rates in an animal model of cancer cachexia.
• Genetic and Immunological Comparison of the Cladoceran Parasite Pasteuria ramosa with the Nematode Parasite Pasteuria penetrans.
• Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts.
• Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.
• IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4.
• Implementation and evaluation of a pilot education programme in colorectal cancer management for nurses in Scotland.
• Long-range protons from the He3 (d,p) alpha-reaction.
• MYOPIA AND PSEUDO-MYOPIA.
• Metropolitan microbes: type III secretion in multihost symbionts.
• Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system.
• OPHTHALMOLOGICAL "NOTES AND QUERIES.".
• Pharmacokinetics and pharmacodynamics of drospirenone-estradiol combination hormone therapy product coadministered with hydrochlorothiazide in hypertensive postmenopausal women.
• Postoperative tonsil bleeding; studies of the etiology, prevention and management.
• Pseudomonas syringae pv. tomato DC3000 Uses Constitutive and Apoplast-Induced Nutrient Assimilation Pathways to Catabolize Nutrients That Are Abundant in the Tomato Apoplast.
• Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method.
• Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin.
• Reactivation of expression from quiescent herpes simplex virus type 1 genomes in the absence of immediate-early protein ICP0.
• Real-time RT-PCR quantification of Kuruma shrimp transcripts: a comparison of relative and absolute quantification procedures.
• Removable prostheses revisited: challenges for primary dental care. 3. Overdentures.
• Structure, function, and regulation of the aldouronate utilization gene cluster from Paenibacillus sp. strain JDR-2.
• Surgical appliance for treating jaw and other facial bone fractures. No. 2,453,934.
• The bilateral distal extension removable partial denture: mechanical problems and solutions.
• The cultivation in vitro of various amphibian tissues.
• The effect of different environments on shallow-water reverberation: Measurements and modeling.
• Thyroxine (T(4)) transfer from CSF to choroid plexus and ventricular brain regions in rabbit: Contributory role of P-glycoprotein and organic anion transporting polypeptides.