Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register.

Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. Research Abstract Details 

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Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. Abstract Text:

Carlos A Vaccaro,Fernando Bonadeo, Roverano,Paivi Peltomaki,Shashi Bala,Elise Renkonen,Maria A Redal,Esteban Mocetti,Eduardo Mullen,Guillermo Ojea-Quintana,Mario L Benati,Hernan Garcia Rivello,Mary B Clark,Jane F Lynch,Henry T Lynch,Carlos A Vaccaro,Fernando Bonadeo, Roverano,Paivi Peltomaki,Shashi Bala,Elise Renkonen,Maria A Redal,Esteban Mocetti,Eduardo Mullen,Guillermo Ojea-Quintana,Mario L Benati,Hernan Garcia Rivello,Mary B Clark,Jane F Lynch,Henry T Lynch,

PURPOSE: The first Argentine experience with epidemiologic, molecular, and genetic counseling data is reported. METHODS: We analyzed 43 families fulfilling Amsterdam criteria identified from a prospective database with data from 779 relatives. RESULTS: Eleven families (25.6 percent) presented as Lynch I, 29 (67.4 percent) as Lynch II, and 3 (7 percent) as Muir-Torre syndrome. Among the 306 affected members, 197 cases of colorectal cancer were identified (mean age at diagnosis, 52.1 (range, 21-90) years). The most frequent extracolonic tumors were gastric adenocarcinoma in males and endometrium adenocarcinoma in females. A high incidence of breast cancer was observed (16 cases among 155 females, crude rate: 11,594.20/100,000). Twenty-seven patients (8.8 percent) developed more than one tumor. These patients were younger than those with only one tumor (45 vs. 51 years; P = 0.001). In 5 of 11 patients who underwent molecular sequencing, a pathologic mutation was found. A novel C deletion at 1910 nucleotide, codon 637, exon 12 of MSH2 gene was identified in a family with a strong aggregation of breast cancer with lack of MSH2 immunohistochemical staining. For 78.2 percent of counseled individuals, this session represented the first time they received information, and 73.9 percent stated that their physicians were unaware of their family background. CONCLUSIONS: Argentine families presented a high incidence of stomach cancer. The elevated incidence of breast cancer and its association with a novel hMSH2 mutation bring to consideration the inclusion of this malignancy as part of the syndrome. A lack of awareness by both physicians and persons at risk was observed.

Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. Publishing Authors By Initials

CA Vaccaro,F Bonadeo,AV Roverano,P Peltomaki,S Bala,E Renkonen,MA Redal,E Mocetti,E Mullen,G Ojea-Quintana,ML Benati,HG Rivello,MB Clark,JF Lynch,HT Lynch,CA Vaccaro,F Bonadeo,AV Roverano,P Peltomaki,S Bala,E Renkonen,MA Redal,E Mocetti,E Mullen,G Ojea-Quintana,ML Benati,HG Rivello,MB Clark,JF Lynch,HT Lynch,

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Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Diseases of the colon and rectum

VOLUME: 50

Page Numbers: 1604-11

Journal Abbreviation: Dis. Colon Rectum

ISSN: 0012-3706

DAY: 15

MONTH: Oct

YEAR: 2007

Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register. Information

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LANGUAGE: eng

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AFFILIATION: Department of Colorectal Surgery, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. carlos.vaccaro@hospitalitaliano.org.ar

Country: United States

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MEDLINETA: Dis Colon Rectum

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