Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome.

Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Research Abstract Details 

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Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Abstract Text:

Familial colorectal cancer (CRC) accounts for 10% to 20% of all cases of CRC. Two major autosomal dominant forms of heritable CRC are familial adenomatous polyposis (FAP) and Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer). Along with the risk for CRC, both syndromes are associated with elevated risk for other tumors. Improved understanding of the genetic basis of these diseases has not only facilitated the identification and screening of at-risk individuals and the development of prophylactic or early-stage intervention strategies but also provided better insight into sporadic CRC. This article reviews the clinical and genetic characteristics of FAP and Lynch syndrome, recommended screening and surveillance practices, and appropriate surgical and nonsurgical interventions.

Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Publishing Authors By Initials

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Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Surgical clinics of North America

VOLUME: 88

Page Numbers: 819-44

Journal Abbreviation: Surg. Clin. North Am.

ISSN: 0039-6109

DAY: 1

MONTH: Aug

YEAR: 2008

Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 74243

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AFFILIATION: Division of General Surgery, Department of Surgery, University of Toronto, 1225-600 University Avenue, Toronto, Ontario, Canada M5G 1X5; Samuel Lunenfeld Research Institute, 1225-600 University Avenue, Toronto, Ontario, Canada M5G 1X5.

Country: United States

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MEDLINETA: Surg Clin North Am

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