Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy.

Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Research Abstract Details 

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Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Abstract Text:

BACKGROUND: Hepatocyte growth factor (HGF) is an endothelium specific growth factor that has been implicated in angiogenesis, a crucial event for the development of proliferative diabetic retinopathy (PDR). The aim of the study is to determine the intravitreous concentrations of HGF in diabetic patients with PDR, and to investigate whether its serum levels could contribute to its intravitreous concentration. METHODS: 17 diabetic patients and seven non-diabetic patients in whom a vitrectomy was performed were studied. Both groups were matched by serum levels of HGF. Venous blood and vitreous samples were collected simultaneously at the time of vitreoretinal surgery. Vitreous and serum HGF were determined by ELISA. RESULTS: Intravitreous concentrations of HGF (median and range) were higher in diabetic patients (17.04 ng/ml (9.98-80)) in comparison with non-diabetic patients (5.88 ng/ml (2.57-14.20); p=0. 003). Intravitreous HGF concentrations were strikingly higher than serum HGF concentrations both in diabetic patients (17.04 ng/ml (9. 98-80) v 0.66 ng/ml (0.26-1.26); p<0.001) and in the control group (5.88 ng/ml (2.57-14.20) v 0.68 ng/ml (0.49-0.96); p=0.003). No correlation was found between serum and vitreous levels of HGF in both groups (diabetic patients, r= -0.31; p=0.5 and control subjects r= -0.15; p=0.5). CONCLUSION: The high vitreous levels of HGF observed in diabetic patients with PDR cannot be attributed to serum diffusion across the blood-retinal barrier. Therefore, intraocular synthesis appears to be the main contributing factor for the high vitreous HGF concentrations in diabetic patients, a cytokine that seems to be directly involved in the pathogenesis of PDR.

Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Publishing Authors By Initials

For similar vitreous body research abstracts see: vitreous body research

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Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 84

Page Numbers: 732-5

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Jul

YEAR: 2000

Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Keywords Mesh Terms:

KEYWORDS: Vitreous Body

MESH TERMS: metabolism

Chemical & Substance for Abstract: Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy. Information

Substance Name: Hepatocyte Growth Factor

Registry Number: 67256-21-7

Grant and Affiliation Information for Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy.

AFFILIATION: Endocrinology Department, Hospital Universitari, Vall d' Hebron, Barcelona, Spain.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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