Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients.

Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients. Research Abstract Details 

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Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients. Abstract Text:

M Yoneda,S Saito,T Ikeda,K Fujita,H Mawatari,H Kirikoshi,M Inamori,Y Nozaki,T Akiyama,H Takahashi,Y Abe,K Kubota,T Iwasaki,Y Terauchi,S Togo,A Nakajima,M Yoneda,S Saito,T Ikeda,K Fujita,H Mawatari,H Kirikoshi,M Inamori,Y Nozaki,T Akiyama,H Takahashi,Y Abe,K Kubota,T Iwasaki,Y Terauchi,S Togo,A Nakajima,

Insulin resistance (IR) is known to be associated with the visceral adipose tissue area. Elucidation of the relationship between hepatitis C virus (HCV) and IR is of great clinical relevance, because IR promotes liver fibrosis. In this study, we tested the hypothesis that HCV infection by itself may promote IR. We prospectively evaluated 47 patients with chronic HCV infection who underwent liver biopsy. Patients with obesity, type 2 diabetes mellitus (DM), or a history of alcohol consumption were excluded. IR was estimated by calculation of the modified homeostasis model of insulin resistance (HOMA-IR) index. Abdominal fat distribution was determined by computed tomography. Fasting blood glucose levels were within normal range in all the patients. The results of univariate analysis revealed a significant correlation between the quantity of HCV-RNA and the HOMA-IR (r = 0.368, P = 0.0291). While a significant correlation between the visceral adipose tissue area and the HOMA-IR was also observed in the 97 control, nondiabetic, non-HCV-infected patients (r = 0.398, P < 0.0001), no such significant correlation between the visceral adipose tissue area and the HOMA-IR (r = 0.124, P = 0.496) was observed in the patients with HCV infection. Multiple regression analysis with adjustment for age, gender and visceral adipose tissue area revealed a significant correlation between the HCV-RNA and the HOMA-IR (P = 0.0446). HCV is directly associated with IR in a dose-dependent manner, independent of the visceral adipose tissue area. This is the first report to demonstrate the direct involvement of HCV and IR in patients with chronic HCV infection.

Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients. Publishing Authors By Initials

M Yoneda,S Saito,T Ikeda,K Fujita,H Mawatari,H Kirikoshi,M Inamori,Y Nozaki,T Akiyama,H Takahashi,Y Abe,K Kubota,T Iwasaki,Y Terauchi,S Togo,A Nakajima,M Yoneda,S Saito,T Ikeda,K Fujita,H Mawatari,H Kirikoshi,M Inamori,Y Nozaki,T Akiyama,H Takahashi,Y Abe,K Kubota,T Iwasaki,Y Terauchi,S Togo,A Nakajima,

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Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of viral hepatitis

VOLUME: 14

Page Numbers: 600-7

Journal Abbreviation: J. Viral Hepat.

ISSN: 1352-0504

DAY: 16

MONTH: Sep

YEAR: 2007

Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients. Information

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LANGUAGE: eng

NlmUniqueID: 9435672

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AFFILIATION: Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Country: England

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MEDLINETA: J Viral Hepat

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