Hepatitis C virus coinfection and superinfection.

Hepatitis C virus coinfection and superinfection. Research Abstract Details 

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Hepatitis C virus coinfection and superinfection. Abstract Text:

Jason T Blackard,Kenneth E Sherman,

A hallmark of RNA viruses is their extreme genetic diversity. Within an individual, the hepatitis C virus (HCV) exists as a population of distinct but closely related viral variants, termed the "viral quasispecies." These variants may display divergent replicative capacity, cell tropism, immunologic escape, and antiviral-drug resistance. Coinfection with 2 or more distinct HCVs has been frequently documented. Moreover, several cases of HCV superinfection have been reported recently. However, few data are available regarding the clinical consequences of coinfection and superinfection, although these phenomena have important implications for HCV vaccine design and development, as well as for the efficacy of HCV therapeutic agents.

Hepatitis C virus coinfection and superinfection. Publishing Authors By Initials

JT Blackard,KE Sherman,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Hepatitis C virus coinfection and superinfection. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 519-24

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 11

MONTH: 01

YEAR: 2007

Hepatitis C virus coinfection and superinfection. Information

Number of References: 63

LANGUAGE: eng

NlmUniqueID: 413675

Hepatitis C virus coinfection and superinfection. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: virology

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Grant and Affiliation Information for Hepatitis C virus coinfection and superinfection.

AFFILIATION: Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. jason.blackard@uc.edu

Country: United States

AGENCY: United States NIDDK

GRANT: K24 DK 070528-01

ACRONYM: DK

MEDLINETA: J Infect Dis

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