Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles.

Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Research Abstract Details 

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Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Abstract Text:

Y Adachi,J Roy-Chowdhury,N Roy-Chowdhury,R Kinne,T Tran,H Kobayashi,I M Arias,

In order to characterize the mechanism for bilirubin transport in the liver, the uptake of bilirubin diglucuronide (BDG) into purified sinusoidal plasma membrane vesicles was investigated. BDG uptake was saturable, and was inhibited by sulfobromophthalein and unconjugated bilirubin, but was not affected by sodium taurocholate. BDG uptake was sodium-independent and was stimulated by intravesicular bilirubin or BDG (trans-stimulation). BDG transport showed strong potential sensitivity; vesicle inside-negative membrane potential created by different anion gradients inhibited BDG uptake whereas vesicle inside-positive membrane potential generated by potassium gradients and valinomycin markedly stimulated BDG transport. These data suggest that BDG, sulfobromophthalein, and probably unconjugated bilirubin share a common transporter in liver cells which is sodium independent, membrane-potential-dependent and capable of exchange. The direction of transport in vivo may be governed by the intracellular concentration of BDG and of other yet unidentified organic anions sharing this transporter.

Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Publishing Authors By Initials

Y Adachi,J Roy-Chowdhury,N Roy-Chowdhury,R Kinne,T Tran,H Kobayashi,IM Arias,

For similar polycyclic compounds: macrocyclic compounds: peptides, cyclic: depsipeptides: valinomycin research abstracts see: polycyclic compounds: macrocyclic compounds: peptides, cyclic: depsipeptides: valinomycin research

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Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biochemistry

VOLUME: 107

Page Numbers: 749-54

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1990

Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Keywords Mesh Terms:

KEYWORDS: Valinomycin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles. Information

Substance Name: Bilirubin

Registry Number: 635-65-4

Grant and Affiliation Information for Hepatic uptake of bilirubin diglucuronide: analysis by using sinusoidal plasma membrane vesicles.

AFFILIATION: Second Department of Internal Medicine, Kinki University School of Medicine, Osaka.

Country: JAPAN

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MEDLINETA: J Biochem

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