Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Research Abstract Details 

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Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Abstract Text:

Kevin R Hayes,Gina M Zastrow,Manabu Nukaya,Kalyan Pande,Ed Glover,John P Maufort,Adam L Liss,Yan Liu,Susan M Moran,Aaron L Vollrath,Christopher A Bradfield,Kevin R Hayes,Gina M Zastrow,Manabu Nukaya,Kalyan Pande,Ed Glover,John P Maufort,Adam L Liss,Yan Liu,Susan M Moran,Aaron L Vollrath,Christopher A Bradfield,Kevin R Hayes,Gina M Zastrow,Manabu Nukaya,Kalyan Pande,Ed Glover,John P Maufort,Adam L Liss,Yan Liu,Susan M Moran,Aaron L Vollrath,Christopher A Bradfield,Kevin R Hayes,Gina M Zastrow,Manabu Nukaya,Kalyan Pande,Ed Glover,John P Maufort,Adam L Liss,Yan Liu,Susan M Moran,Aaron L Vollrath,Christopher A Bradfield,

The environmental contaminant 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) serves as a prototype for a range of environmental toxicants and as a pharmacologic probe to study signal transduction by the aryl hydrocarbon receptor (AHR). Despite a detailed understanding of how TCDD exposure leads to the transcriptional up-regulation of cytochrome P450-dependent monooxygenases, we know little about how compounds like TCDD lead to a variety of AHR-dependent toxic end points such as liver pathology, terata, thymic involution, and cancer. Using an acute exposure protocol and the toxic response of the mouse liver as a model system, we have begun a detailed microarray analysis to describe the transcriptional changes that occur after various TCDD doses and treatment times. Through correlation analysis of time- and dose-dependent toxicological end points, we are able to identify coordinately responsive transcriptional events that can be defined as primary transcriptional events and downstream events that may represent mechanistically linked sequelae or that have potential as biomarkers of toxicity.

Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Publishing Authors By Initials

KR Hayes,GM Zastrow,M Nukaya,K Pande,E Glover,JP Maufort,AL Liss,Y Liu,SM Moran,AL Vollrath,CA Bradfield,KR Hayes,GM Zastrow,M Nukaya,K Pande,E Glover,JP Maufort,AL Liss,Y Liu,SM Moran,AL Vollrath,CA Bradfield,KR Hayes,GM Zastrow,M Nukaya,K Pande,E Glover,JP Maufort,AL Liss,Y Liu,SM Moran,AL Vollrath,CA Bradfield,KR Hayes,GM Zastrow,M Nukaya,K Pande,E Glover,JP Maufort,AL Liss,Y Liu,SM Moran,AL Vollrath,CA Bradfield,

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Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical research in toxicology

VOLUME: 20

Page Numbers: 1573-81

Journal Abbreviation: Chem. Res. Toxicol.

ISSN: 0893-228X

DAY: 20

MONTH: 10

YEAR: 2007

Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Information

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LANGUAGE: eng

NlmUniqueID: 8807448

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Grant and Affiliation Information for Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

AFFILIATION: Bradfield@oncology.wisc.edu.

Country: United States

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MEDLINETA: Chem Res Toxicol

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