Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system.

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Abstract Text:

Fu Zhang,Qi Wu,Zhi-Chun Chen,Ming Zhang,Xian-Fu Lin,Fu Zhang,Qi Wu,Zhi-Chun Chen,Ming Zhang,Xian-Fu Lin,Fu Zhang,Qi Wu,Zhi-Chun Chen,Ming Zhang,Xian-Fu Lin,

We describe the construction of hepatic-targeting microcapsules by self-assembly of chemo-enzymatic synthesized poly(vinyl galactose ester-co-methacryloxyethyl trimethylammonium chloride) (PGEDMC) containing galactose branches, which can be specifically recognized by membrane bound galactose receptors (ASGPR), for acyclovir (ACV) controlled release system. Alternate deposition of PGEDMC and poly(sodium 4-styrenesulfonate) (PSS) was carried out on ACV microcrystals. It was revealed that the drug release rate decreases with the increase of coated layer number and a microcapsule-drying treatment would enhance the sustained release effect probably because of a multilayer shrink and tightness during the process. The complete release of ACV yielded a hollow PGEDMC/PSS multilayered network with favorable integrity and nano-thickness by TEM and SEM. The potential targetability of the system was proved in vitro by PNA lectin recognition. Lectin hardly adsorbed on the film where the outmost layer was a polyanion or a polycation without galactose component. Whilst the galactose-containing layer (PGEDMC) was the outmost layer, a significant lectin combination was observed. This technique could provide a promising way to encapsulate and deliver various target substances in biological and pharmaceutical applications.

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Publishing Authors By Initials

F Zhang,Q Wu,ZC Chen,M Zhang,XF Lin,F Zhang,Q Wu,ZC Chen,M Zhang,XF Lin,F Zhang,Q Wu,ZC Chen,M Zhang,XF Lin,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of colloid and interface science

VOLUME: 317

Page Numbers: 477-84

Journal Abbreviation:

ISSN: 0021-9797

DAY: 29

MONTH: 09

YEAR: 2007

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43125

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system.

AFFILIATION: Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Colloid Interface Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system Related Publications

• A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates.
• Antropyloroduodenal motility after resection of esophageal cancer.
• Family practice graduate preparedness in the six ACGME competency areas: prequel.
• Identification of MUC5B mucin gene in human middle ear with chronic otitis media.
• Multiple suppressor gene p16 of human brain gliomas.
• Requirement of a novel gene, Xin, in cardiac morphogenesis.
• Signal irreproducibility in high-field solution magnetic resonance experiments caused by spin turbulence.
• The effects of simulated microgravity on cultured chicken embryonic chondrocytes.
• Vitamin E succinate potentiates the inhibitory effect of prostaglandins on oral squamous carcinoma cell proliferation.
• [A novel bcl-2 antisense oligodeoxynucleotide F951 increases sensitivity of HL-60 cells to Ara-C]
• [Analysis of essential oil from Artemisia annul L. by extraction of different methods]
• [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]
• [Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis]
• [Cephalometric comparison of soft-tissue morphology between extraction and non-extraction orthodontic treatment in borderline cases.]
• [Clinical evaluation of two tooth preparation methods of metal-porcelain restoration]
• [Clinical study on changes of heme oxygenase-1 expression in patients with acute myocardial infarction]
• [Cloning and expression of heavy- and light-chain variable region genes of monoclonal antibody specific for human fibrin]
• [Diagnosis of lesions in the major abdominal blood vessels by three-dimensional dynamic contrast-enhanced magnetic resonance angiography]
• [Effect of cyclosporin A on intracellular accumulation and efflux of drug in K562/DOX cells]
• [Effects of catecholamines on human preadipocyte proliferation and differentiation]
• [Establishment and characterization of a neural stem cell line (RNSC-FMU 1) from rat brain]
• [Expression and significance of nitric oxide synthase in human hepatocellular carcinoma]
• [Mechanism of injury by active oxygen radical to hemoglobin]
• [Recent researches on fungal hydrophobins]
• [Stability of molar relationship after orthodontic treatment in Class II division 1 malocclusions treated by extraction]
• [Studies on purgative activity of rhubarb extracts by different technologies]
• [Study on induction of leukemic cell apoptosis by antisense oligodeoxynucleotide of human telomerase RNA]
• [Susceptibility to endometriosis in women of Han Nationality in Guangdong Province associated with Msp I polymorphisms of cytochrome P450 1A1 gene]
• [The endocrinological function of ghrelin]
• [Three-dimensional measurement of tooth inclination in cases with successful treatment]