Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse.

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Abstract Text:

The purpose of this experiment was to evaluate the etiology of hepatic dysfunction in patients difficult to wean from cardiopulmonary bypass. We hypothesized that increased central venous pressure and subsequent hepatic congestion during weaning from cardiopulmonary bypass would lead to hepatic dysfunction. To induce hepatic congestion in mice, we clamped the hepatic vein for fifteen min, and observed the microcirculation of the liver using an intravital microscope during clamping and the following 30 min of reperfusion. During reperfusion, non-reflow phenomenon, leukocytes adhesion to the wall of sinusoids, erythrocytes sludging, acute swelling of hepatic cells and narrowing of sinusoids were observed. These phenomena were indicative of warm ischemia-reperfusion injury of the liver itself. Based on these findings we concluded that, after repeated episodes of warm ischemia and reperfusion of the liver, hepatic cells would be damaged, and finally hepatic dysfunction was induced. To prevent hepatic dysfunction, repeated attempts to wean the patient from cardiopulmonary bypass should be avoided and increases central venous pressure should be prevented by early use of cardiopulmonary support.

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Publishing Authors By Initials

For similar surgical procedures, operative: cardiovascular surgical procedures: reperfusion research abstracts see: surgical procedures, operative: cardiovascular surgical procedures: reperfusion research

PUBMED ID PMID:

MEDLINE DATE:

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Kobe journal of medical sciences

VOLUME: 44

Page Numbers: 199-203

Journal Abbreviation: Kobe J Med Sci

ISSN: 0023-2513

DAY: 8

MONTH: Dec

YEAR: 1998

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413531

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Keywords Mesh Terms:

KEYWORDS: Reperfusion

MESH TERMS: physiology

Chemical & Substance for Abstract: Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse.

AFFILIATION: Department of Surgery, Kobe University School of Medicine, ICAM Co., Ltd.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Kobe J Med Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hepatic microcirculation during transient hepatic venous occlusion--intravital microscopic observation using hepatic vein clamp model in the mouse Related Publications

• A case of subclinical hypothyroidism developing marked pleural effusions and peripheral edema with elevated vascular endothelial growth factor.
• C-Type natriuretic peptide/guanylate cyclase B system in rat osteogenic ROB-C26 cells and its down-regulation by dexamethazone.
• Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet.
• Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes.
• Characterization of a novel tyrosine permease of lager brewing yeast shared by Saccharomyces cerevisiae strain RM11-1a.
• Cross-linking of intact erythrocyte membrane with a newly synthesized cleavable bifunctional reagent.
• Cystic lymphangioma of the gallbladder: report of a case.
• Deconstruction of the endoscope: completing my wish list.
• Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.
• High mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest.
• High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle.
• Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma.
• Isolation and some properties of two fragments with inhibitory activity obtained from adzuki bean proteinase inhibitor by peptic digestion.
• Issues and challenges in nursing and nursing education in Japan.
• Localization of the phlorizin site on Na, K-ATPase in red cell membranes.
• Organ secificity of rat sodium- and potassium-activated adenosine triphosphatase.
• Ouabain-sensitive Mg++-ATPase, K+-ATPase and Na+-ATPase activities accompanying a highly specific Na+-K+-ATPase preparation.
• P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma.
• Permeabilization of phospholipid bilayer membranes induced by gas-liquid flow in an airlift bubble column.
• Phase-locking of spontaneous and tone-elicited pontine waves to hippocampal theta waves during REM sleep in rats.
• Proceedings: Multiplicity of Na, K-ATPase.
• Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
• Short-term Effects of Pitavastatin on Biochemical Markers of Bone Turnover in Patients with Hypercholesterolemia.
• TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.
• The aconitase of yeast. II. Crystallization and general properties of yeast aconitase.
• The aconitase of yeast. IV. Studies on iron and sulfur in yeast aconitase.
• The aconitase of yeast. V. The reconstitution of yeast aconitase.
• Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone.
• [Stimulation of bone formation by statins]
• [Successful use of cladribine in the treatment of an elderly woman with typical hairy cell leukemia]