Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial.

Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial. Research Abstract Details 

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Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial. Abstract Text:

Mercedes Del Cotillo,Núria Grané,Maria Llavoré,Salvador Quintana,

OBJECTIVES: The objectives were to analyze the effectiveness of heparinized solution vs. saline solution for the maintenance of arterial catheters and to detect changes in the activated partial thromboplastin time (aPTT) and platelet count in the samples extracted from both groups of arterial catheters. DESIGN: Randomized, double blind, placebo-controlled clinical trial. SETTING: Intensive Care Unit of a third-level hospital in Terrassa, Barcelona, Spain. PATIENTS: One hundred and thirty-three patients were included in the trial. The selection criteria were: adults, informed consent, not receiving either full-dose anticoagulant or fibrinolytic treatment, and no thrombocytopenia. INTERVENTIONS: Sixty-five patients received heparinized solution (1[Symbol: see text]IU/ml) and 68 received saline solution. MEASUREMENTS: Arterial catheter functionality was compared in the groups every 8[Symbol: see text]h and at catheter removal. Patency, reliability of arterial pressure, and curve quality were used to evaluate the functionality of the catheters. Blood was drawn, discarding 7.5[Symbol: see text]ml, from the arterial catheter and from the venouscatheter simultaneously for coagulation tests. RESULTS: The median duration of catheters being in place was 5.1 days (IQR[Symbol: see text]=[Symbol: see text]8.1) in the heparin group, and 5.4 (IQR[Symbol: see text]=[Symbol: see text]7.3) in the saline group (p[Symbol: see text]=[Symbol: see text]0.7). Kaplan-Meier curves showed no differences between groups (p[Symbol: see text]=[Symbol: see text]0.6). The number of manipulations required to maintain the patency of the arterial catheters was 35% vs. 40% (p[Symbol: see text]=[Symbol: see text]0.5). The heparin group had a significantly longer aPTT (2.1[Symbol: see text]+/-[Symbol: see text]1.3 vs. 1.25[Symbol: see text]+/-[Symbol: see text]0.3, p[Symbol: see text]=[Symbol: see text]0.001). CONCLUSIONS: The use of heparinized solution for arterial catheter maintenance doesnot appear to be justified. It did not increase the duration of the catheters, nor did it improve their functionality significantly. On the other hand, heparin Na altered aPTT significantly.

Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial. Publishing Authors By Initials

M Del Cotillo,N Grané,M Llavoré,S Quintana,

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Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Intensive care medicine

VOLUME: 34

Page Numbers: 339-43

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ISSN: 0342-4642

DAY: 16

MONTH: 10

YEAR: 2007

Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial. Information

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LANGUAGE: eng

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AFFILIATION: Intensive Care Unit (ICU), Hospital Mútua de Terrassa, Plaza Dr. Robert 5, 08221, Terrassa, Barcelona, Spain, mercedes7870@hotmail.com.

Country: United States

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MEDLINETA: Intensive Care Med

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