Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.

Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Research Abstract Details 

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Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Abstract Text:

Ikenna G Madu,Victor C Chu,Hwajin Lee,Andrew D Regan,Beverley E Bauman,Gary R Whittaker,

The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.

Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Publishing Authors By Initials

IG Madu,VC Chu,H Lee,AD Regan,BE Bauman,GR Whittaker,

For similar proteins: viral proteins: viral structural proteins: viral envelope proteins research abstracts see: proteins: viral proteins: viral structural proteins: viral envelope proteins research

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MEDLINE DATE:

Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Avian diseases

VOLUME: 51

Page Numbers: 45-51

Journal Abbreviation:

ISSN: 0005-2086

DAY: 3

MONTH: Mar

YEAR: 2007

Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370617

Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Keywords Mesh Terms:

KEYWORDS: Viral Envelope Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette. Information

Substance Name: Heparitin Sulfate

Registry Number: 9050-30-0

Grant and Affiliation Information for Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.

AFFILIATION: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R03 AI060946

ACRONYM: AI

MEDLINETA: Avian Dis

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