Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice.

Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Research Abstract Details 

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Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Abstract Text:

Longitudinal studies of hematocrits were done in aging B6D2F1 female mice at 54, 64, 91, 105 and 115 weeks of age. A modest decline in hematocrit was observed in 41/42 mice; we have previously shown that the decreased hematocrit of aged as compared to young mice is due to an expansion of plasma volume. Mice which died spontaneously after 91 weeks had lower hematocrits at 91 weeks and 105 weeks than did those which survived to 115 weeks. At each time interval, a sub-group of mice was killed and uptake of 59Fe into blood, foreleg, spleen and liver was studied and total nucleated cells per humerus was determined. The results were generally compatible with the thesis that aging mice maintain normal rates of erythropoiesis under basal conditions. Thus, it would appear that a decrease in hematocrit can be considered an expected part of the aging process in this mouse.

Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Publishing Authors By Initials

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains research

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Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental aging research

VOLUME: 12

Page Numbers: 131-4

Journal Abbreviation:

ISSN: 0361-073X

DAY: 25

MONTH: 02

YEAR: 1986

Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603335

Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred Strains

MESH TERMS: physiology

Chemical & Substance for Abstract: Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice. Information

Substance Name: Iron Radioisotopes

Registry Number: 0

Grant and Affiliation Information for Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NIADDK

GRANT: 2 R01 AM14352-16

ACRONYM: AM

MEDLINETA: Exp Aging Res

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