Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity.

Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity. Research Abstract Details 

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Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity. Abstract Text:

Yutaro Nakamura,Payal Watchmaker,Julie Urban,Brian Sheridan,Adam Giermasz,Fumihiko Nishimura,Kotaro Sasaki,Rachel Cumberland,Ravikumar Muthuswamy,Robbie B Mailliard,Adriana T Larregina,Louis D Falo,William Gooding,Walter J Storkus,Hideho Okada,Robert L Hendricks,Pawel Kalinski,Yutaro Nakamura,Payal Watchmaker,Julie Urban,Brian Sheridan,Adam Giermasz,Fumihiko Nishimura,Kotaro Sasaki,Rachel Cumberland,Ravikumar Muthuswamy,Robbie B Mailliard,Adriana T Larregina,Louis D Falo,William Gooding,Walter J Storkus,Hideho Okada,Robert L Hendricks,Pawel Kalinski,

In contrast to the well-established efficacy of preventive vaccines, the effectiveness of therapeutic vaccines remains limited. To develop effective vaccination regimens against cancer, we have analyzed the effect of effector and memory CD8+ T cells on the ability of dendritic cells to mediate the immunologic and antitumor effects of vaccination. We show that in contrast to effector CD8+ T cells that kill antigen-carrying dendritic cells, IFNgamma-producing memory CD8+ T cells act as "helper" cells, supporting the ability of dendritic cells to produce interleukin-12 (IL-12) p70. Promoting the interaction of tumor antigen-carrying dendritic cells with memory-type "heterologous" (tumor-irrelevant) CD8+ T cells strongly enhances the IL-12p70-dependent immunogenic and therapeutic effects of vaccination in the animals bearing established tumors. Our data show that the suppressive and helper functions of CD8+ T cells are differentially expressed at different phases of CD8+ T-cell responses. Selective performance of helper functions by memory (in contrast to effector) CD8+ T cells helps to explain the phenomenon of immune memory and facilitates the design of effective therapeutic vaccines against cancer and chronic infections.

Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity. Publishing Authors By Initials

Y Nakamura,P Watchmaker,J Urban,B Sheridan,A Giermasz,F Nishimura,K Sasaki,R Cumberland,R Muthuswamy,RB Mailliard,AT Larregina,LD Falo,W Gooding,WJ Storkus,H Okada,RL Hendricks,P Kalinski,Y Nakamura,P Watchmaker,J Urban,B Sheridan,A Giermasz,F Nishimura,K Sasaki,R Cumberland,R Muthuswamy,RB Mailliard,AT Larregina,LD Falo,W Gooding,WJ Storkus,H Okada,RL Hendricks,P Kalinski,

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Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 67

Page Numbers: 10012-8

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Oct

YEAR: 2007

Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity.

AFFILIATION: Department of Surgery, University of Pittsburgh, Eye and Ear Institute, PA 15213-1863, USA.

Country: United States

AGENCY: United States NCI

GRANT: 1R01CA095128

ACRONYM: CA

MEDLINETA: Cancer Res

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