Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation.

Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation. Research Abstract Details 

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Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation. Abstract Text:

S Futagami,T Hiratsuka,T Shindo,T Hamamoto,N Ueki,K Suzuki,M Kusunoki,K Wada,K Miyake,K Ohashi,K Gudis,T Tsukui,C Sakamoto,

Background We investigated factors that impact gammadelta T-cell phenotype accumulation in Helicobacter pylori-infected gastric mucosa and peripheral blood. Aim To determine whether H. pylori infection induces accumulation of Vdelta1 T cells via CC chemokine receptor 2 (CCR2) upregulation. Methods Mucosal biopsy samples from 22 H. pylori-free and 75 H. pylori-infected patients were classified into grades I-III gastritis groups as per our previous study. The number of gammadelta, Vdelta1 and Vdelta2 T cells was evaluated by immunostaining and then compared with counts in 17 patients after H. pylori eradication. TGF-beta, IFN-gamma and CCR2 mRNA expression levels in Vdelta1 T cells stimulated by H. pylori component were also evaluated. Results gammadelta T-cell count was significantly higher in grade III gastritis patients, who exhibited strong IgA and IgG responses to H. pylori urease, than in other groups. Vdelta1 T cells were found dominantly residing in H. pylori-infected gastric mucosa, whereas Vdelta2 T cells were mainly found in peripheral blood. Vdelta1 T-cell count was significantly reduced after H. pylori eradication therapy. In in vitro studies, H. pylori component stimulation significantly upregulated both TGF-beta and IFN-gamma production in supernatant from stimulated Vdelta1 T cells. Moreover, CCR2 mRNA expression in Vdelta1 T cells stimulated with H. pylori components was significantly increased. Conclusion Accumulation of Vdelta1 T cells may occur through the upregulation of CCR2 expression.

Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation. Publishing Authors By Initials

S Futagami,T Hiratsuka,T Shindo,T Hamamoto,N Ueki,K Suzuki,M Kusunoki,K Wada,K Miyake,K Ohashi,K Gudis,T Tsukui,C Sakamoto,

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Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Alimentary pharmacology & therapeutics

VOLUME: 24 Suppl 4

Page Numbers: 8-15

Journal Abbreviation: Aliment. Pharmacol. Ther.

ISSN: 0269-2813

DAY: 9

MONTH: Dec

YEAR: 2006

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LANGUAGE: eng

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AFFILIATION: Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

Country: England

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MEDLINETA: Aliment Pharmacol Ther

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