Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes.

Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Research Abstract Details 

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Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Abstract Text:

Masako Ogura,J Christian Perez,Peer R E Mittl,Hae-Kyung Lee,Geidrius Dailide,Shumin Tan,Yoshiyuki Ito,Ousman Secka,Daiva Dailidiene,Kalyani Putty,Douglas E Berg,Awdhesh Kalia,Masako Ogura,J Christian Perez,Peer R E Mittl,Hae-Kyung Lee,Geidrius Dailide,Shumin Tan,Yoshiyuki Ito,Ousman Secka,Daiva Dailidiene,Kalyani Putty,Douglas E Berg,Awdhesh Kalia,

Geographic partitioning is postulated to foster divergence of Helicobacter pylori populations as an adaptive response to local differences in predominant host physiology. H. pylori's ability to establish persistent infection despite host inflammatory responses likely involves active management of host defenses using bacterial proteins that may themselves be targets for adaptive evolution. Sequenced H. pylori genomes encode a family of eight or nine secreted proteins containing repeat motifs that are characteristic of the eukaryotic Sel1 regulatory protein, whereas the related Campylobacter and Wolinella genomes each contain only one or two such "Sel1-like repeat" (SLR) genes ("slr genes"). Signatures of positive selection (ratio of nonsynonymous to synonymous mutations, dN/dS = omega > 1) were evident in the evolutionary history of H. pylori slr gene family expansion. Sequence analysis of six of these slr genes (hp0160, hp0211, hp0235, hp0519, hp0628, and hp1117) from representative East Asian, European, and African H. pylori strains revealed that all but hp0628 had undergone positive selection, with different amino acids often selected in different regions. Most striking was a divergence of Japanese and Korean alleles of hp0519, with Japanese alleles having undergone particularly strong positive selection (omegaJ > 25), whereas alleles of other genes from these populations were intermingled. Homology-based structural modeling localized most residues under positive selection to SLR protein surfaces. Rapid evolution of certain slr genes in specific H. pylori lineages suggests a model of adaptive change driven by selection for fine-tuning of host responses, and facilitated by geographic isolation. Characterization of such local adaptations should help elucidate how H. pylori manages persistent infection, and potentially lead to interventions tailored to diverse human populations.

Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Publishing Authors By Initials

M Ogura,JC Perez,PR Mittl,HK Lee,G Dailide,S Tan,Y Ito,O Secka,D Dailidiene,K Putty,DE Berg,A Kalia,M Ogura,JC Perez,PR Mittl,HK Lee,G Dailide,S Tan,Y Ito,O Secka,D Dailidiene,K Putty,DE Berg,A Kalia,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

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MEDLINE DATE:

Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: PLoS computational biology

VOLUME: 3

Page Numbers: e151

Journal Abbreviation: PLoS Comput. Biol.

ISSN: 1553-7358

DAY: 19

MONTH: 06

YEAR: 2007

Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101238922

Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: methods

Chemical & Substance for Abstract: Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes. Information

Substance Name: Ubx2 protein, S cerevisiae

Registry Number: 0

Grant and Affiliation Information for Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes.

AFFILIATION: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK063041

ACRONYM: DK

MEDLINETA: PLoS Comput Biol

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ACCESSION NUMBER: EF372923

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