Height and Alzheimer's disease: findings from a case-control study.

Height and Alzheimer's disease: findings from a case-control study. Research Abstract Details 

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Height and Alzheimer's disease: findings from a case-control study. Abstract Text:

Grace J Petot,Ursula Vega,Fatoumata Traore,Thomas Fritsch,Sara M Debanne,Robert P Friedland,Alan J Lerner,

The purpose of this study is to examine the relationship of height, Apolipoprotein E genotype (APOE) and Alzheimer's disease (AD). Using a case-control design, subjects were recruited from the research registry of the University Memory and Aging Center of Case Western Reserve University and University Hospitals of Cleveland. On entry to the study, height was measured on 239 probable or possible AD patients and 341 healthy controls living in northeast Ohio. Risk of AD was modeled as a function of quartile of height, APOE genotype, years of education and year of birth. Analyses were stratified by gender. For men, cases were more likely to be shorter when compared to controls (p=0.001). There was only a small difference in mean height between AD cases and controls among women (p=0.05). For men, height in the highest quartile [>179.7 cm (70.75 in)] had a 59% lower risk of developing AD that in the lowest quartile [< 169.5 cm (66.75 in)], controlling for year of birth, and education (p=0.03). For women without an APOE epsilon4 allele, increasing height was associated with lower risk for AD (OR=0.88; p=0.01) but no significant association was found for women with at least one epsilon4 allele (OR=1.03; p=0.56).

Height and Alzheimer's disease: findings from a case-control study. Publishing Authors By Initials

GJ Petot,U Vega,F Traore,T Fritsch,SM Debanne,RP Friedland,AJ Lerner,

For similar epidemiologic measurements: demography: sex distribution research abstracts see: epidemiologic measurements: demography: sex distribution research

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Height and Alzheimer's disease: findings from a case-control study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of Alzheimer's disease : JAD

VOLUME: 11

Page Numbers: 337-41

Journal Abbreviation: J. Alzheimers Dis.

ISSN: 1387-2877

DAY: 3

MONTH: Jun

YEAR: 2007

Height and Alzheimer's disease: findings from a case-control study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9814863

Height and Alzheimer's disease: findings from a case-control study. Keywords Mesh Terms:

KEYWORDS: Sex Distribution

MESH TERMS: metabolism

Chemical & Substance for Abstract: Height and Alzheimer's disease: findings from a case-control study. Information

Substance Name: Apolipoprotein E4

Registry Number: 0

Grant and Affiliation Information for Height and Alzheimer's disease: findings from a case-control study.

AFFILIATION: Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. grace.petot@case.edu

Country: Netherlands

AGENCY: United States NIA

GRANT: R01AG01717 3-0482

ACRONYM: AG

MEDLINETA: J Alzheimers Dis

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