Heat shock proteins in human endometrium throughout the menstrual cycle.

Heat shock proteins in human endometrium throughout the menstrual cycle. Research Abstract Details 

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Heat shock proteins in human endometrium throughout the menstrual cycle. Abstract Text:

S Tabibzadeh,J Broome,

Human endometrium, in response to steroid hormones, undergoes characteristic cycles of proliferation, secretory changes, and tissue shedding. Human endometrium expresses a molecular repertoire which includes the heat shock proteins (Hsps) Hsp27, Hsp60, Hsp70, Hsp90, and alpha crystallin B chain. The expression of Hsp27, Hsp60, and the constitutive form of Hsp70 (Hsc70) shows a sharp increase in human endometrium after ovulation. The maximal expression of the molecular chaperone, alpha crystallin B chain, occurs during the secretory phase. In view of known functions of the Hsps, it is likely that these proteins are involved in protection of the endometrial proteins against factors with the potential to lead to protein denaturation. Tumor necrosis factor-alpha (TNF-alpha) is a cytotoxic cytokine that is produced in progressive amounts during the secretory phase. The function of the Hsps may be to protect cells against the cytotoxic damage of TNF-alpha, particularly during the critical period of "implantation window."

Heat shock proteins in human endometrium throughout the menstrual cycle. Publishing Authors By Initials

S Tabibzadeh,J Broome,

For similar reproductive and urinary physiology: reproduction: menstrual cycle research abstracts see: reproductive and urinary physiology: reproduction: menstrual cycle research

PUBMED ID PMID:

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Heat shock proteins in human endometrium throughout the menstrual cycle. Journal Published:

PUBLICATION TYPE: Review

Journal: Infectious diseases in obstetrics and gynecology

VOLUME: 7

Page Numbers: 5-9

Journal Abbreviation: Infect Dis Obstet Gynecol

ISSN: 1064-7449

DAY: 21

MONTH: 01

YEAR: 1999

Heat shock proteins in human endometrium throughout the menstrual cycle. Information

Number of References: 45

LANGUAGE: eng

NlmUniqueID: 9318481

Heat shock proteins in human endometrium throughout the menstrual cycle. Keywords Mesh Terms:

KEYWORDS: Menstrual Cycle

MESH TERMS: metabolism

Chemical & Substance for Abstract: Heat shock proteins in human endometrium throughout the menstrual cycle. Information

Substance Name: Heat-Shock Proteins

Registry Number: 0

Grant and Affiliation Information for Heat shock proteins in human endometrium throughout the menstrual cycle.

AFFILIATION: Department of Pathology, North Shore University Hospital, Biomedical Research Center, Manhasset, NY 11030, USA. tabibzadeh@bioscience.org

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA46866

ACRONYM: CA

MEDLINETA: Infect Dis Obstet Gynecol

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