Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE.

Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE. Research Abstract Details 

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Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE. Abstract Text:

David M Latini,June M Chan,Janet E Cowan,Shelley A Arredondo,Christopher J Kane,David F Penson,Janeen DuChane,Peter R Carroll, ,

OBJECTIVES: To compare diabetic versus nondiabetic men with prostate cancer to understand whether diabetes mellitus (DM) imposes an additional burden on health-related quality of life (HRQOL) before and after radical prostatectomy, adjusting for obesity. METHODS: Data were abstracted from Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE), a disease registry of 12,005 men with localized prostate cancer. Men were included who had undergone surgical treatment from 1989 to 2003, had body mass index (BMI) information available, and had completed both a pretreatment and at least one posttreatment HRQOL questionnaire within 24 months. A repeated-measures model adjusted for baseline clinical and demographic variables was used to evaluate group differences. RESULTS: The 1248 men were divided into two groups (117 with DM and 1131 without DM) on the basis of a history of DM or the reporting of diabetes medication use. The diabetic men were significantly more likely to be older and nonwhite, have lower education and income, and be less likely to have private insurance. They also had significantly more comorbid conditions (other than DM) and a greater BMI at baseline. Urinary function differed by diabetes status, BMI, and the DM x BMI interaction, with diabetic men who had a greater BMI reporting greater declines in urinary function over time. No other statistically significant differences in HRQOL were observed, although trends by BMI were noted in sexual function and bowel bother. CONCLUSIONS: Although previous studies of men with prostate cancer have found differences in HRQOL by obesity level, our results have indicated that the presence or absence of DM and a high BMI may have a greater impact on HRQOL than obesity alone.

Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE. Publishing Authors By Initials

DM Latini,JM Chan,JE Cowan,SA Arredondo,CJ Kane,DF Penson,J DuChane,PR Carroll, ,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research

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Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Urology

VOLUME: 68

Page Numbers: 1242-7

Journal Abbreviation: Urology

ISSN: 1527-9995

DAY: 4

MONTH: 12

YEAR: 2006

Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE. Information

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LANGUAGE: eng

NlmUniqueID: 366151

Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE. Keywords Mesh Terms:

KEYWORDS: Retrospective Studies

MESH TERMS: surgery

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Grant and Affiliation Information for Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE.

AFFILIATION: Scott Department of Urology and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA. latini@bcm.tmc.edu

Country: United States

AGENCY: United States PHS

GRANT: P50 C89520

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MEDLINETA: Urology

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