Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2.

Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Research Abstract Details 

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Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Abstract Text:

K Ohura,C Hamanishi,S Tanaka,N Matsuda,

A beta-tricalcium phosphate-monocalcium phosphate monohydrate (beta-TCP-MCPM) cement was evaluated as an effective carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in rat femoral critical-size defects. Hard cement cylinders (4 x 5 mm) impregnated with two different doses of rhBMP-2 (1.26 or 6.28 microg) were implanted into each defect, and the results were compared with those in rats that had implantations of cylinders only. Implantation of the 6.28 microg dose of rhBMP-2 caused a large bone shell to form around the defect, resulting in osseous union in all cases within 3 weeks. Except for beta-TCP granules, the cement was resorbed and replaced by bone tissue at 6 weeks. A torsion test at 9 weeks showed that the failure torque and bone stiffness had recovered 99% and 141%, respectively, compared with the intact contralateral femur. The defects that received 1.26 microg of rhBMP-2 resulted in 40% union and 41% of the failure torque at 9 weeks. However, no instances of union were observed in the defects implanted with cylinders only. In conclusion, the beta-TCP-MCPM cement was shown to be effective as a rhBMP-2 carrier. Combined with rhBMP-2, this cement was rapidly resorbed and completely healed the defects.

Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Publishing Authors By Initials

K Ohura,C Hamanishi,S Tanaka,N Matsuda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research

VOLUME: 44

Page Numbers: 168-75

Journal Abbreviation: J. Biomed. Mater. Res.

ISSN: 0021-9304

DAY: 19

MONTH: Feb

YEAR: 1999

Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Information

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LANGUAGE: eng

NlmUniqueID: 112726

Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2.

AFFILIATION: Department of Orthopaedic Surgery, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.

Country: UNITED STATES

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MEDLINETA: J Biomed Mater Res

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