Headache in children with sickle cell disease: prevalence and associated factors.

Headache in children with sickle cell disease: prevalence and associated factors. Research Abstract Details 

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Headache in children with sickle cell disease: prevalence and associated factors. Abstract Text:

Alison E Niebanck,Avrum N Pollock,Kim Smith-Whitley,Leslie J Raffini,Robert A Zimmerman,Kwaku Ohene-Frempong,Janet L Kwiatkowski,

OBJECTIVE: To compare the prevalence of frequent headache in children with sickle cell disease (SCD) to that of black control subjects and to assess factors associated with headache in SCD. STUDY DESIGN: In this cross-sectional study, a headache questionnaire was administered to subjects with SCD and black control subjects. Subjects answered supplementary questions about SCD complications. Clinical and radiographic information were abstracted from medical charts for subjects with SCD. RESULTS: Children (n = 241) with SCD and 141 control subjects were studied; 32.4% (95% CI 26.5%-38.7%) of subjects with SCD reported having headaches at least weekly, similar to control subjects at 27% (95% CI 19.8%-35.1%, P = NS); however, in children <13 years, headache was more common in subjects with SCD than in control subjects (24% vs 9.7%, P = .013). The prevalence of headache was similar among the different SCD genotypes. Factors associated with frequent headaches in subjects with SCD included older age, frequent vaso-occlusive pain episodes, symptoms of obstructive sleep apnea, and cerebral vessel stenosis detected by magnetic resonance angiography. CONCLUSION: The prevalence of headaches in children with SCD is similar to the general population; however, younger children with SCD report headaches more frequently than control subjects. The cause of headache is likely multifactorial, and SCD-specific factors may contribute.

Headache in children with sickle cell disease: prevalence and associated factors. Publishing Authors By Initials

AE Niebanck,AN Pollock,K Smith-Whitley,LJ Raffini,RA Zimmerman,K Ohene-Frempong,JL Kwiatkowski,

For similar epidemiologic measurements: demography: sex distribution research abstracts see: epidemiologic measurements: demography: sex distribution research

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Headache in children with sickle cell disease: prevalence and associated factors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of pediatrics

VOLUME: 151

Page Numbers: 67-72, 72.e1

Journal Abbreviation: J. Pediatr.

ISSN: 1097-6833

DAY: 3

MONTH: Jul

YEAR: 2007

Headache in children with sickle cell disease: prevalence and associated factors. Information

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LANGUAGE: eng

NlmUniqueID: 375410

Headache in children with sickle cell disease: prevalence and associated factors. Keywords Mesh Terms:

KEYWORDS: Sex Distribution

MESH TERMS: epidemiology

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Grant and Affiliation Information for Headache in children with sickle cell disease: prevalence and associated factors.

AFFILIATION: Duke University School of Medicine, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 2 P60 HL38632

ACRONYM: HL

MEDLINETA: J Pediatr

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