HDAC3: taking the SMRT-N-CoRrect road to repression.

HDAC3: taking the SMRT-N-CoRrect road to repression. Research Abstract Details 

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HDAC3: taking the SMRT-N-CoRrect road to repression. Abstract Text:

P Karagianni,J Wong,

Known histone deacetylases (HDACs) are divided into different classes, and HDAC3 belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT and N-CoR, HDAC3 regulates the transcription of a plethora of genes. A growing list of nonhistone substrates extends the role of HDAC3 beyond transcriptional repression. Here, we review data on the composition, regulation and mechanism of action of the SMRT/N-CoR-HDAC3 complexes and provide several examples of nontranscriptional functions, to illustrate the wide variety of physiological processes affected by this deacetylase. Furthermore, we discuss the implication of HDAC3 in cancer, focusing on leukemia. We conclude with some thoughts about the potential therapeutic efficacies of HDAC3 activity modulation.

HDAC3: taking the SMRT-N-CoRrect road to repression. Publishing Authors By Initials

P Karagianni,J Wong,

For similar genetic processes: gene expression regulation: protein modification, translational: protein processing, post-translational research abstracts see: genetic processes: gene expression regulation: protein modification, translational: protein processing, post-translational research

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HDAC3: taking the SMRT-N-CoRrect road to repression. Journal Published:

PUBLICATION TYPE: Review

Journal: Oncogene

VOLUME: 26

Page Numbers: 5439-49

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 13

MONTH: Aug

YEAR: 2007

HDAC3: taking the SMRT-N-CoRrect road to repression. Information

Number of References: 125

LANGUAGE: eng

NlmUniqueID: 8711562

HDAC3: taking the SMRT-N-CoRrect road to repression. Keywords Mesh Terms:

KEYWORDS: Protein Processing, Post-Translational

MESH TERMS: metabolism

Chemical & Substance for Abstract: HDAC3: taking the SMRT-N-CoRrect road to repression. Information

Substance Name: histone deacetylase 3

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for HDAC3: taking the SMRT-N-CoRrect road to repression.

AFFILIATION: Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Country: England

AGENCY: United States NIDDK

GRANT: DK58679

ACRONYM: DK

MEDLINETA: Oncogene

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