HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women.

HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Abstract Text:

E B Levitan,S Liu,M J Stampfer,N R Cook,K M Rexrode,P M Ridker,J E Buring,J E Manson,

AIMS/HYPOTHESIS: Diabetes is known to increase mortality rate, but the degree to which mild hyperglycaemia may be associated with the risk of death is uncertain. We examined the association between HbA(1c) measured in stored erythrocytes and mortality rate in women with and without diabetes. METHODS: We conducted a cohort study of 27,210 women >/= 45 years old with no history of cardiovascular disease or cancer who participated in the Women's Health Study, a randomised trial of vitamin E and aspirin. RESULTS: Over a median of 10 years of follow-up, 706 women died. Proportional hazards models adjusted for age, smoking, hypertension, blood lipids, exercise, postmenopausal hormone use, multivitamin use and C-reactive protein were used to estimate the relative risk of mortality. Among women without a diagnosis of diabetes and HbA(1c) <5.60%, those in the top quintile (HbA(1c) 5.19-5.59%) had a relative risk of mortality of 1.28 (95% CI 0.98-1.69, p value for linear trend = 0.14) compared with those with HbA(1c) 2.27-4.79%. Women with HbA(1c) 5.60-5.99% and no diagnosis of diabetes had a 54% increased risk of mortality (95% CI 1-136%) compared with those with HbA(1c) 2.27-4.79%. HbA(1c) was significantly associated with mortality across the range 4.50-7.00% (p value for linear trend = 0.02); a test of deviation from linearity was not statistically significant (p = 0.67). Diabetic women had more than twice the mortality risk of non-diabetic women. CONCLUSIONS/INTERPRETATION: This study provides further evidence that chronic mild hyperglycaemia, even in the absence of diagnosed diabetes, is associated with increased risk of mortality. ClinicalTrials.gov ID no.: NCT00000479.

HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Publishing Authors By Initials

EB Levitan,S Liu,MJ Stampfer,NR Cook,KM Rexrode,PM Ridker,JE Buring,JE Manson,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Diabetologia

VOLUME: 51

Page Numbers: 267-75

Journal Abbreviation: Diabetologia

ISSN: 0012-186X

DAY: 28

MONTH: 11

YEAR: 2007

HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 6777

HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women.

AFFILIATION: Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, MS 443, Boston, MA, 02215, USA, elevitan@bidmc.harvard.edu.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Diabetologia

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

HbA1c measured in stored erythrocytes and mortality rate among middle-aged and older women Related Publications

• A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.
• A psychometric analysis of psychoneurotic and psychosomatic characteristics of alcoholics.
• A psychometric analysis of psychopathic characteristics of alcoholics.
• A psychometric determination of alcoholic addiction.
• A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study.
• A simple method of assessing premenstrual syndrome in large prospective studies.
• ANAEMIA AS AN AETIOLOGICAL FACTOR IN CONVERGENCE INSUFFICIENCY.
• Allelic variants in HOX genes in cryptorchidism.
• Association between diabetes and mental disorders in two American Indian reservation communities.
• Cognitive impairment, psychiatric disorders, and problematic behaviors in a tribal nursing home.
• Conduct disorder, war zone stress, and war-related posttraumatic stress disorder symptoms in American Indian Vietnam veterans.
• Diagnostic reliability of telepsychiatry in American Indian veterans.
• Dietary intakes of flavonols and flavones and coronary heart disease in US women.
• Disparities in drug use and disorder: comparison of two American Indian reservation communities and a national sample.
• Expression of nuclear notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt.
• Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.
• Hand evaluation following ulnar forearm perforator flap harvest: a prospective study.
• HbA(1c) measured in stored erythrocytes and mortality rate among middle-aged and older women.
• High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.
• Metabolism of polycyclic compounds. 9. Metabolism of 2-naphthylamine in rat tissue slices.
• Microanalyses of enzymes and metabolites in ischemia/reperfusion-induced partial-thickness skin wounds.
• My genes made me do it? The implications of behavioural genetics for responsibility and blame.
• Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.
• Rare gas collisions with molten metal surfaces.
• Suboptimal pharmacotherapy in a tribal nursing home.
• The biochemistry of aromatic amines. 4. O-glucosiduronic acid derivatives of 2-naphthylamine.
• The biochemistry of aromatic amines. 5. 2-Aceta-mido-6-hydroxy-5-naphthyl hydrogen sulphate and other metabolites of 2-naphthylamine and 2-aceta-midonaphthalene.
• The metabolism of 2-naphthylamine in rat tissue slices.
• The metabolites of 2-naphthylamine produced by rats and rabbits.
• Tuning a bacterial chemoreceptor with protein-membrane interactions.