Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells.

Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Research Abstract Details 

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Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Abstract Text:

Ching Ching Leow,Maria S Romero,Sarajane Ross,Paul Polakis,Wei-Qiang Gao,

A striking feature of colon tumors is the significant reduction of goblet cells. Although targeted deletion of Math1 in mice leads to a loss of intestinal secretory cells, including goblet cells, the role of Hath1 in colon tumorigenesis remains unknown. Here we report that Hath1, the human ortholog of Math1, was dramatically down-regulated in colon tumor samples and colon cancer cell lines. Overexpression of Hath1 in HT29, an aggressive colon cancer cell line, resulted in a significant inhibition on cell proliferation, anchorage-independent growth in soft agar and, more importantly, growth of human colon cancer cell xenografts in athymic nude mice. Such inhibition was accompanied by altered expression of a goblet cell differentiation marker, MUC2, and cell cycle regulators cyclin D1 and p27kip1. Hath1 expression also was up-regulated on inhibition of the Wnt pathway, which has been well implicated in colon tumorigenesis. Hence, this study suggests that Hath1 may be a novel factor downstream of the Wnt pathway capable of suppressing anchorage-independent growth of colon cancer cell lines. More importantly, this study is the first to establish a link between down-regulation of Hath1 expression and colon tumorigenesis.

Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Publishing Authors By Initials

CC Leow,MS Romero,S Ross,P Polakis,WQ Gao,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

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Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer research

VOLUME: 64

Page Numbers: 6050-7

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Sep

YEAR: 2004

Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Information

Substance Name: Cyclin-Dependent Kinase Inhibitor p27

Registry Number: 147604-94-2

Grant and Affiliation Information for Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells.

AFFILIATION: Department of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

Country: United States

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MEDLINETA: Cancer Res

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