Harpooning the Cvt complex to the phagophore assembly site.

Harpooning the Cvt complex to the phagophore assembly site. Research Abstract Details 

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Harpooning the Cvt complex to the phagophore assembly site. Abstract Text:

Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradation. In addition to the random bulk elimination of cytoplasmic contents, the selective removal of specific cargo molecules has also been described. These selective types of autophagy are characterized by the recruitment of the cargo destined for degradation in close proximity to the forming double-membrane vesicle that results in an exclusive incorporation (that is, without bulk cytoplasm). A number of factors required for selective types of autophagy have been identified. In particular, we have recently shown that actin and the actin-binding Arp2/3 protein complex are involved in the cytoplasm to vacuole targeting (Cvt) pathway, a yeast selective type of autophagy. The contribution at a molecular level of these factors, however, remains unknown. In this addendum, we present mechanistic models that take into account possible roles of actin and the Arp2/3 complex in the Cvt pathway.

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Harpooning the Cvt complex to the phagophore assembly site. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Autophagy

VOLUME: 4

Page Numbers: 914-6

Journal Abbreviation: Autophagy

ISSN: 1554-8635

DAY: 24

MONTH: 10

YEAR: 2008

Harpooning the Cvt complex to the phagophore assembly site. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Harpooning the Cvt complex to the phagophore assembly site.

AFFILIATION: Department of Cell Biology and Institute of Biomembranes, University Medical Centre Utrecht, Utrecht, the Netherlands.

Country: United States

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MEDLINETA: Autophagy

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