Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension.

Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Abstract Text:

Masaaki Tamura,Tomohiro Nakayama,Ichiro Sato,Naoyuki Sato,Noriko Izawa,Mikano Hishiki,Yoshihiro Mizutani,Kiyohide Furuya,Tatsuo Yamamoto,

Hypotheses about pregnancy-induced hypertension (PIH) have been proposed to explain the vascular damage that characterizes this disease. Reports indicate that estrogens and estrogen receptors play important physiological roles in cardiovascular diseases. There have been studies examining the association between coronary artery disease and the estrogen receptor alpha (ESR1) gene. The aim of the present work was to assess the association between PIH and single-nucleotide polymorphisms (SNPs) in the human ESR1 gene, by conducting a haplotype-based case-control study. Based on a database search at the web site of the National Center of Biotechnology Information, we chose five SNPs in the human ESR1 gene, and performed an association study using 95 PIH patients and 200 age-matched non-PIH subjects. The frequency of rs2881766 genotypes and alleles differed significantly between the two groups. There was no significant difference in overall distribution of genotypes or alleles of the other four SNPs. The T allele of rs2881766 was significantly more prevalent in the PIH group than in the non-PIH group. Haplotype-based case-control analysis revealed that there was a significant difference in overall distribution of the combinations rs2881766-rs1643821-rs988328 and rs2881766-rs1643821 between the PIH group and the non-PIH group (all or body mass index [BMI]-matched). One susceptibility haplotype for PIH and two resistance haplotypes for PIH were revealed by comparison between the PIH group and the non-PIH (BMI-matched) control group. In conclusion, the T allele of rs2881766 could be a useful genetic marker of PIH. The G-A-T haplotype of rs2881766-rs1643821-rs988328 and the G-A haplotype of rs2881766-rs1643821 appear to be resistance markers of PIH. (Hypertens Res 2008; 31: 221-228).

Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Publishing Authors By Initials

M Tamura,T Nakayama,I Sato,N Sato,N Izawa,M Hishiki,Y Mizutani,K Furuya,T Yamamoto,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hypertension research : official journal of the Ja

VOLUME: 31

Page Numbers: 221-8

Journal Abbreviation: Hypertens. Res.

ISSN: 0916-9636

DAY: 24

MONTH: Feb

YEAR: 2008

Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9307690

Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Haplotype-Based Case-Control Study of Estrogen Receptor alpha (ESR1) Gene and Pregnancy-Induced Hypertension.

AFFILIATION: Department of Obstetrics and Gynecology, Nihon University School of Medicine.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hypertens Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Haplotype-Based Case-Control Study of Estrogen Receptor alpha ESR1 Gene and Pregnancy-Induced Hypertension Related Publications

• CO2-enhanced sonographically guided radiofrequency ablation and transcatheter arterial chemoembolization for small hepatocellular carcinoma poorly defined on conventional sonography.
• Contested dominance modifies the anovulatory consequences of social subordination in female marmosets.
• Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.
• Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002.
• Diastereo- and enantioselective synthesis of nitroso Diels-Alder-type bicycloketones using dienamine: mechanistic insight into sequential nitroso Aldol/Michael reaction and application for optically pure 1-amino-3,4-diol synthesis.
• Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme.
• Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.
• Effects of bilateral jugular vein ligation on local cerebral blood flow.
• Effects of brain lesions on taste-potentiated odor aversion in rats.
• Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function.
• Evaluation of osteogenic/chondrogenic cellular proliferation and differentiation in the xenogeneic periosteal graft.
• Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma.
• Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata.
• Imaging of Regional Differences of Muscle Oxygenation during Exercise Using Spatially Resolved NIRS.
• Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction.
• Intraoperative electro-oculographic Monitoring for Skull Base Surgery.
• Involvement of the Mesolimbic System in Palatability-induced Ingestion.
• Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.
• Kinetic mechanism of the fastest motor protein, Chara myosin.
• Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
• Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
• Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
• Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.
• Regulation of Wnt signalling by receptor-mediated endocytosis.
• Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression.
• The Role of Orexigenic Neuropeptides in the Ingestion of Sweet-tasting Substances in Rats.
• The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology.
• The use of polylactic acid/polyglycolic acid copolymer and gelatin sponge complex containing human recombinant bone morphogenetic protein-2 following condylectomy in rabbits.
• Trehalose Sensitivity of the Gustatory Receptor Neurons Expressing Wild-type, Mutant and Ectopic Gr5a in Drosophila.