Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Abstract Text:

Ana C Barbosa,Noriko Funato,Shelby Chapman,Marc D McKee,James A Richardson,Eric N Olson,Hiromi Yanagisawa,Ana C Barbosa,Noriko Funato,Shelby Chapman,Marc D McKee,James A Richardson,Eric N Olson,Hiromi Yanagisawa,

Hand proteins are evolutionally conserved basic helix-loop-helix (bHLH) transcription factors implicated in development of neural crest-derived tissues, heart and limb. Hand1 is expressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain extends ventrolaterally to occupy two-thirds of the mandibular arch. To circumvent the early embryonic lethality of Hand1 or Hand2-null embryos and to examine their roles in neural crest development, we generated mice with neural crest-specific deletion of Hand1 and various combinations of mutant alleles of Hand2. Ablation of Hand1 alone in neural crest cells did not affect embryonic development, however, further removing one Hand2 allele or deleting the ventrolateral branchial arch expression of Hand2 led to a novel phenotype presumably due to impaired growth of the distal midline mesenchyme. Although we failed to detect changes in proliferation or apoptosis between the distal mandibular arch of wild-type and Hand1/Hand2 compound mutants at embryonic day (E)10.5, dysregulation of Pax9, Msx2 and Prx2 was observed in the distal mesenchyme at E12.5. In addition, the inter-dental mesenchyme and distal symphysis of Meckel's cartilage became hypoplastic, resulting in the formation of a single fused lower incisor within the hypoplastic fused mandible. These findings demonstrate the importance of Hand transcription factors in the transcriptional circuitry of craniofacial and tooth development.

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Publishing Authors By Initials

AC Barbosa,N Funato,S Chapman,MD McKee,JA Richardson,EN Olson,H Yanagisawa,AC Barbosa,N Funato,S Chapman,MD McKee,JA Richardson,EN Olson,H Yanagisawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 310

Page Numbers: 154-68

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 3

MONTH: 08

YEAR: 2007

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.

AFFILIATION: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dev Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Hand transcription factors cooperatively regulate development of the distal midline mesenchyme Related Publications

• An essential role for orexins in emergence from general anesthesia.
• Application of the personal aeroallergen sampler to assess personal exposures to Japanese cedar and cypress pollens.
• Bariatric surgery for morbid obesity-a cure for metabolic syndrome?
• Comparative studies on actins from various sources. Fragments of actins from Ascaris muscle cleaved at cysteinyl residues in comparison with those of other actins.
• Conversion of prothrombin into thrombin. I. DEAE-cellulose chromatography of prothrombin and isolation of a prothrombin derivative.
• Distinct modulations of the hexokinase1-mediated glucose response and hexokinase1-independent processes by HYS1/CPR5 in Arabidopsis.
• Effect of glucose and adenosine 3', 5'-cyclic monophosphate on the early development of Dictyostelium discoideum.
• Emergence of telithromycin resistance in Haemophilus influenzae in Japan.
• Endoscopic view of sinonasal cancer 6 years post-treatment.
• Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.
• Epistaxis caused by hemangioma of the inferior turbinate.
• Glycosignaling in neural stem cells: involvement of glycoconjugates in signal transduction modulating the neural stem cell fate.
• Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.
• Heart disease in Nepali children.
• Lack of circadian regulation of in vitro melatonin release from the pineal organ of salmonid teleosts.
• Metabolic syndrome and type 2 diabetes: can we stop the weight gain with diabetes?
• Microdetermination of 1-Methylheptyl gamma-bromoacetoacetate in human blood.
• Molecular evolution of prepro-thyrotropin-releasing hormone in the chicken (Gallus gallus) and its expression in the brain.
• Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness.
• Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
• Progressive decrease in heteronymous monosynaptic Ia facilitation with human ageing.
• Rotational Raman scattering of hydrogen for calibrating a Thomson scattering device.
• Sequential activation of two Dof transcription factor gene promoters during vascular development in Arabidopsis thaliana.
• Sex-role reversal of a monogamous pipefish without higher potential reproductive rate in females.
• The use of a telescope in sinus balloon dilation.
• Ultrasound contrast agent, Levovist microbubbles are phagocytosed by Kupffer cells-In vitro and in vivo studies.
• [A study of cardiac pacing. An effect of indifferent electrodes of cardiac pacemaker for the stimulation current threshold and intracardiac R wave (author's transl)]
• [Analyses of protein experssion profile to explorer molecular mechanisms of intiation and progression in non-small cell lung cancer]
• [Planning of wards in hospital]
• [The evaluation of myocardial protection from ischemia by means of 31P-NMR--the role of changes in myocardial high-energy phosphate levels]