Hairy cell leukemia. Bone marrow findings in 24 patients.

Hairy cell leukemia. Bone marrow findings in 24 patients. Research Abstract Details 

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Hairy cell leukemia. Bone marrow findings in 24 patients. Abstract Text:

K F Vykoupil,J Thiele,A Georgii,

In 24 patients with hairy cell leukemia, histological and fine structural findings from biopsies of the bone marrow are reported and their validity is compared with other diagnostic procedures available. Diagnosis by light microscopy of anterior iliac crest biopsies obtained by the method of myelotomy is possible with a high degree of accuracy. The differentiation of hairy cell leukemia from other myelo- or lymphoproliferative disorders based on cytomorphology as well as patterns of growth is emphasized. Morphological differences between fibrosis in this entity and other lesions such as malignant lymphomas, Hodgkin's disease, osteomyelofibrosis and -sclerosis are emphasized. Electron microscopy of the bone marrow shows single fibroblastic cells with numerous slender cytoplasmic processes randomly dispersed among the hairy cells. These fibroblasts are probably responsible for the synthesis of the reticulin and collagen fibres in their surroundings. Moreover fine structur of the hairy cells demonstrates pinocytic activity but no apparent phagocytosis in contrast to the phagocytic reticulum cells (histiocytes, macrophages). In the bone marrow the precursor cells and the many immature forms of hairy cells exhibit an overall lymphocytoid appearance during their maturation, suggesting a lymphocytic origin.

Hairy cell leukemia. Bone marrow findings in 24 patients. Publishing Authors By Initials

KF Vykoupil,J Thiele,A Georgii,

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Hairy cell leukemia. Bone marrow findings in 24 patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv. A, Pathological anatomy and histo

VOLUME: 370

Page Numbers: 273-89

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ISSN: 0340-1227

DAY: 21

MONTH: Jul

YEAR: 1976

Hairy cell leukemia. Bone marrow findings in 24 patients. Information

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LANGUAGE: eng

NlmUniqueID: 7505137

Hairy cell leukemia. Bone marrow findings in 24 patients. Keywords Mesh Terms:

KEYWORDS: Phagocytes

MESH TERMS: pathology

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Country: GERMANY, WEST

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MEDLINETA: Virchows Arch A Pathol Anat Hi

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