Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage.

Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Research Abstract Details 

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Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Abstract Text:

Rita Marchi,Ysabel ,Chandrasekaran Nagaswami,Leona Masova,Anibal Pulido, ,Aixa Muller,Carmen Luisa ,John W Weisel,

We have studied some biophysical properties of the fibrin network during the normal state of pregnancy and in patients with recurrent miscarriage (RM), in the first trimester of pregnancy. The fibrin polymerization process, followed by turbidity, showed that the rate of fibrin monomer assembly and the final turbidity was increased in the pregnant group (normal and with history of RM) compared to non-pregnant women (normal and RM), which is consistent with the increased fibrinogen concentration during pregnancy. No changes were observed in the Darcy constant (Ks) of RM clots, pregnant or not; however, in pregnant control subjects the Ks increased (p = 0.03). The fibrin lysis rate was increased in pregnant women compared to non-pregnant, being faster in women with RM. The rheological properties of the fibrin network in the non-pregnant group (control and RM patients) were similar; in the pregnant state, the fibrin network of the control group was 1.3 times stiffer compared to the control non-pregnant women, and almost unchanged in RM patients. In this study we have found changes in the clot structure that seem to be related to normal pregnancy and an increased rate of the fibrin lysis process in the RM patients, which may have clinical relevance.

Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Publishing Authors By Initials

R Marchi,Y ,C Nagaswami,L Masova,A Pulido,J ,A Muller,CL ,JW Weisel,

For similar geographic locations: americas: south america: venezuela research abstracts see: geographic locations: americas: south america: venezuela research

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Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Thrombosis and haemostasis

VOLUME: 97

Page Numbers: 552-7

Journal Abbreviation: Thromb. Haemost.

ISSN: 0340-6245

DAY: 3

MONTH: Apr

YEAR: 2007

Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608063

Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Keywords Mesh Terms:

KEYWORDS: Venezuela

MESH TERMS: blood

Chemical & Substance for Abstract: Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Information

Substance Name: Fibrin

Registry Number: 9001-31-4

Grant and Affiliation Information for Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage.

AFFILIATION: Centro de Medicina Experimental, Laboratorio Biología del Desarollo de la Hemostasia, Instituto Venezolano de Investigaciones Científicas, IVIC Apartado 21827, Caracas, Venezuela. rmarchi@medicina.ivic.ve

Country: Germany

AGENCY: United States NHLBI

GRANT: HL30954

ACRONYM: HL

MEDLINETA: Thromb Haemost

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