Haemophilus ducreyi is susceptible to protegrin.

Haemophilus ducreyi is susceptible to protegrin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Haemophilus ducreyi is susceptible to protegrin. Abstract Text:

Protegrins, potent antimicrobial peptides found in porcine leukocytes, have activity against the sexually transmitted pathogens Neisseria gonorrhoeae, Chlamydia trachomatis, and human immunodeficiency virus type 1. We tested synthetic protegrin 1 (PG-1) for activity against nine isolates of Haemophilus ducreyi, the etiologic agent of chancroid. The test organisms included CIP 542 (the type strain), 35000HP (a human-passaged variant of 35000), 35000HP-RSM2 (an isogenic D-glycero-D-manno-heptosyltransferase mutant of 35000HP), and six clinical isolates. The isolates were epidemiologically unrelated, represented three HindIII ribotypes, and had varying antimicrobial resistance patterns. In bactericidal assays, five isolates were rapidly killed by synthetic PG-1. In radial diffusion assays, all nine isolates were exquisitely sensitive to PG-1. These data highlight the potential of protegrins for development as topical agents to prevent many sexually transmitted diseases, including chancroid.

Haemophilus ducreyi is susceptible to protegrin. Publishing Authors By Initials

For similar proteins research abstracts see: proteins research

PUBMED ID PMID:

MEDLINE DATE:

Haemophilus ducreyi is susceptible to protegrin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Antimicrobial agents and chemotherapy

VOLUME: 42

Page Numbers: 2690-3

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 23

MONTH: Oct

YEAR: 1998

Haemophilus ducreyi is susceptible to protegrin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 315061

Haemophilus ducreyi is susceptible to protegrin. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Haemophilus ducreyi is susceptible to protegrin. Information

Substance Name: protegrin-1

Registry Number: 0

Grant and Affiliation Information for Haemophilus ducreyi is susceptible to protegrin.

AFFILIATION: Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana 46202, USA.

Country: UNITED STATES

AGENCY: United States NIAID

GRANT: AI31494

ACRONYM: AI

MEDLINETA: Antimicrob Agents Chemother

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Haemophilus ducreyi is susceptible to protegrin Related Publications

• Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers.
• Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication.
• Haemophilus ducreyi is susceptible to protegrin.
• Haemophilus ducreyi partially activates human myeloid dendritic cells.
• Identification of Haemophilus ducreyi genes expressed during human infection.
• Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers.