Haemodynamic and neural responses to hypercapnia in the awake rat.

Haemodynamic and neural responses to hypercapnia in the awake rat. Research Abstract Details 

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Haemodynamic and neural responses to hypercapnia in the awake rat. Abstract Text:

Chris Martin,Myles Jones,John Martindale,John Mayhew,

The relationship between localized changes in brain activity and metabolism, and the blood oxygenation level-dependent (BOLD) signal used in functional magnetic resonance imaging studies is not fully understood. One source of complexity is that stimulus-elicited changes in the BOLD signal arise both from changes in oxygen consumption due to increases in activity and purely 'haemodynamic' changes such as increases in cerebral blood flow. It is well established that robust cortical haemodynamic changes can be elicited by increasing the concentration of inspired CO(2) (inducing hypercapnia) and it is widely believed that these haemodynamic changes occur without significant effects upon neural activity or cortical metabolism. Hypercapnia is therefore commonly used as a calibration condition in functional magnetic resonance imaging studies to enable estimation of oxidative metabolism from subsequent stimulus-evoked functional magnetic resonance imaging BOLD signal changes. However, there is little research that has investigated in detail the effects of hypercapnia upon all components of the haemodynamic response (changes in cerebral blood flow, volume and oxygenation) in addition to recording neural activity. In awake animals, we used optical and electrophysiological techniques to measure cortical haemodynamic and field potential responses to hypercapnia (60 s, 5% CO(2)). The main findings are that firstly, in the awake rat, the temporal structure of the haemodynamic response to hypercapnia differs from that reported previously in anaesthetized preparations in that the response is more rapid. Secondly, there is evidence that hypercapnia alters ongoing neural activity in awake rats by inducing periods of cortical desynchronization and this may be associated with changes in oxidative metabolism.

Haemodynamic and neural responses to hypercapnia in the awake rat. Publishing Authors By Initials

C Martin,M Jones,J Martindale,J Mayhew,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Haemodynamic and neural responses to hypercapnia in the awake rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 24

Page Numbers: 2601-10

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 3

MONTH: Nov

YEAR: 2006

Haemodynamic and neural responses to hypercapnia in the awake rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Haemodynamic and neural responses to hypercapnia in the awake rat. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: analysis

Chemical & Substance for Abstract: Haemodynamic and neural responses to hypercapnia in the awake rat. Information

Substance Name: deoxyhemoglobin

Registry Number: 9008-02-0

Grant and Affiliation Information for Haemodynamic and neural responses to hypercapnia in the awake rat.

AFFILIATION: Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. c.j.martin@shef.ac.uk

Country: France

AGENCY: United States NINDS

GRANT: 1R01NS044567-011

ACRONYM: NS

MEDLINETA: Eur J Neurosci

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