H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers.

H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Research Abstract Details 

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H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Abstract Text:

Marat V Avshalumov,Li Bao,Jyoti C Patel,Margaret E Rice,

The role of reactive oxygen species (ROS) as signaling agents is increasingly appreciated. Studies of ROS functions in the central nervous system, however, are only in their infancy. Using fast-scan cyclic voltammetry and fluorescence imaging in brain slices, the authors discovered that hydrogen peroxide (H2O2) is an endogenous regulator of dopamine release in the dorsal striatum. Given the key role of dopamine in motor, reward, and cognitive pathways, regulation by H2O2 has implications for normal dopamine function, as well as for dysfunction of dopamine transmission. In this review, data are summarized to show that H2O2 is a diffusible messenger in the striatum, generated downstream from glutamate receptor activation, and an intracellular signal in dopamine neurons of the substantia nigra, generated during normal pacemaker activity. The mechanism by which H2O2 inhibits dopamine release and dopamine cell activity is activation of ATP-sensitive K+ (KATP) channels. Characteristics of the neuronal and glial antioxidant networks required to permit H2O2 signaling, yet prevent oxidative damage, are also considered. Lastly, estimates of physiological H2O2 levels are discussed, and strengths and limitations of currently available methods for H2O2 detection, including fluorescence imaging using dichlorofluorescein (DCF) and the next generation of fluorescent probes, are considered.

H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Publishing Authors By Initials

MV Avshalumov,L Bao,JC Patel,ME Rice,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Journal Published:

PUBLICATION TYPE: Review

Journal: Antioxidants & redox signaling

VOLUME: 9

Page Numbers: 219-31

Journal Abbreviation:

ISSN: 1523-0864

DAY: 3

MONTH: Feb

YEAR: 2007

H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100888899

H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: chemistry

Chemical & Substance for Abstract: H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers. Information

Substance Name: Hydrogen Peroxide

Registry Number: 7722-84-1

Grant and Affiliation Information for H2O2 signaling in the nigrostriatal dopamine pathway via ATP-sensitive potassium channels: issues and answers.

AFFILIATION: Department of Neurosurgery and Department of Physiology and Neuroscience, New York University School of Medicine, New York 10016, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS-45325

ACRONYM: NS

MEDLINETA: Antioxid Redox Signal

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