H pylori infection causes chronic pancreatitis in Mongolian gerbils.

H pylori infection causes chronic pancreatitis in Mongolian gerbils. Research Abstract Details 

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H pylori infection causes chronic pancreatitis in Mongolian gerbils. Abstract Text:

Gabriele Rieder,Arno Karnholz,Mechthild Stoeckelhuber,Juanita L Merchant,Rainer Haas,

AIM: To investigate whether chronic H pylori infection has the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type IV secretion system. METHODS: Mongolian gerbils were infected with wild type (WT) H pylori type I strain B128 or its isogenic mutant B128 deltacagY (defective type IV secretion). After seven months of infection, H pylori was reisolated from antrum and corpus and H pylori DNA was analyzed by semi-nested polymerase chain reaction (PCR). Inflammation and histological changes were documented in the gastric antrum, corpus, and pancreas by immunohistochemistry. Cytokine mRNA, gastric pH, plasma gastrin, amylase, lipase, and glucose levels were determined. RESULTS: The H pylori infection rate was 95%. Eight infected animals, but none of the uninfected group, developed transmural inflammation and chronic pancreatitis. Extensive interstitial fibrosis and inflammation of the pancreatic lobe adjacent to the antrum was confirmed by trichrome stain, and immuno-histochemically. Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils. In the corpus, only cytokine levels of WT-infected animals and those developing transmural inflammation and pancreatitis were significantly increased. Levels of lipase, but not glucose or amylase levels, were significantly reduced in the pancreatitis group. H pylori DNA was detected in infected antral and corpus tissue, but not in the pancreas. CONCLUSION: H pylori infection is able to induce chronic pancreatitis in Mongolian gerbils independently of the type IV secretion system, probably by an indirect mechanism associated with a penetrating ulcer.

H pylori infection causes chronic pancreatitis in Mongolian gerbils. Publishing Authors By Initials

G Rieder,A Karnholz,M Stoeckelhuber,JL Merchant,R Haas,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, radioisotope: radioimmunoassay research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, radioisotope: radioimmunoassay research

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MEDLINE DATE:

H pylori infection causes chronic pancreatitis in Mongolian gerbils. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: World journal of gastroenterology : WJG

VOLUME: 13

Page Numbers: 3939-47

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 7

MONTH: Aug

YEAR: 2007

H pylori infection causes chronic pancreatitis in Mongolian gerbils. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883448

H pylori infection causes chronic pancreatitis in Mongolian gerbils. Keywords Mesh Terms:

KEYWORDS: Radioimmunoassay

MESH TERMS: metabolism

Chemical & Substance for Abstract: H pylori infection causes chronic pancreatitis in Mongolian gerbils. Information

Substance Name: Amylases

Registry Number: EC 3.2.1.-

Grant and Affiliation Information for H pylori infection causes chronic pancreatitis in Mongolian gerbils.

AFFILIATION: Max von Pettenkofer-Institute, Pettenkoferstr. 9a, D-80336 Munich, Germany. rieder@mvp.uni-muenchen.de

Country: China

AGENCY: United States NIDDK

GRANT: R01DK45729

ACRONYM: DK

MEDLINETA: World J Gastroenterol

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