Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana.

Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Research Abstract Details 

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Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Abstract Text:

Jian-Guang Luo,Xiao-Bing Wang,Li Ma,Ling-Yi Kong,Jian-Guang Luo,Xiao-Bing Wang,Li Ma,Ling-Yi Kong,

An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against alpha-glucosidase with IC50 of 305 microM.

Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Publishing Authors By Initials

JG Luo,XB Wang,L Ma,LY Kong,JG Luo,XB Wang,L Ma,LY Kong,

For similar enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: glucosidases: alpha-glucosidases research abstracts see: enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: glucosidases: alpha-glucosidases research

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Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 4460-3

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 8

MONTH: 06

YEAR: 2007

Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Keywords Mesh Terms:

KEYWORDS: alpha-Glucosidases

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana. Information

Substance Name: alpha-Glucosidases

Registry Number: EC 3.2.1.20

Grant and Affiliation Information for Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana.

AFFILIATION: Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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