Gynecomastia possibly induced by rosuvastatin.

Gynecomastia possibly induced by rosuvastatin. Research Abstract Details 

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Gynecomastia possibly induced by rosuvastatin. Abstract Text:

Alessandro Oteri,Maria Antonietta Catania,Rita Travaglini,Alessandra Russo,Saffi E Giustini,Achille P Caputi,Giovanni Polimeni,

Abstract Gynecomastia is characterized by benign progressive enlargement of the male breast. A pharmacologic origin is identified in 10-20% of cases. Several case reports have associated this condition to the use of statins. However, to our knowledge, no case of rosuvastatin-induced gynecomastia has been reported in the literature. We describe a 57-year-old man who developed bilateral gynecomastia after 2 months of rosuvastatin therapy. After switching to a different statin, atorvastatin, his symptoms resolved within 1 month. Use of the Naranjo adverse drug reaction probability scale indicated a possible relationship between the patient's development of gynecomastia and rosuvastatin therapy. The relatively strong effect of rosuvastatin on inhibiting steroidogenesis might have explained why our patient's gynecomastia occurred only with this agent. Clinicians should be aware of the possibility of adverse endocrine reactions when statins are prescribed, including newer agents such as rosuvastatin.

Gynecomastia possibly induced by rosuvastatin. Publishing Authors By Initials

A Oteri,MA Catania,R Travaglini,A Russo,SE Giustini,AP Caputi,G Polimeni,

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Gynecomastia possibly induced by rosuvastatin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacotherapy

VOLUME: 28

Page Numbers: 549-51

Journal Abbreviation: Pharmacotherapy

ISSN: 0277-0008

DAY: 26

MONTH: Apr

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 8111305

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Grant and Affiliation Information for Gynecomastia possibly induced by rosuvastatin.

AFFILIATION: 1 Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy.

Country: United States

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MEDLINETA: Pharmacotherapy

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