Growth trajectory during early life and risk of adult schizophrenia.

Growth trajectory during early life and risk of adult schizophrenia. Research Abstract Details 

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Growth trajectory during early life and risk of adult schizophrenia. Abstract Text:

Megan A Perrin,Henian Chen,David E Sandberg,Dolores Malaspina,Alan S Brown,Megan A Perrin,Henian Chen,David E Sandberg,Dolores Malaspina,Alan S Brown,

BACKGROUND: Growth abnormalities have been suggested as a precursor to schizophrenia, but previous studies have not assessed growth patterns using repeated measures. AIMS: To assess the association between early life/later childhood growth patterns and risk of schizophrenia. METHODS: Using prospectively collected data from a birth cohort (born 1959-1967), measurements of height, weight and body mass index (BMI) were analysed to compare growth patterns during early life and later childhood between 70 individuals with schizophrenia-spectrum disorder (SSD) and 7710 without. RESULTS: For women, growth in the SSD group was approximately 1 cm/year slower during early life (P < 0.01); no association was observed for men. Later childhood growth was not associated with SSD. Weight patterns were not associated with SSD, whereas slower change in BMI was observed among the SSD group during later childhood. CONCLUSIONS: The association between slower growth in early life and schizophrenia in women suggests that factors responsible for regulating growth might be important in the pathogenesis of the disorder.

Growth trajectory during early life and risk of adult schizophrenia. Publishing Authors By Initials

MA Perrin,H Chen,DE Sandberg,D Malaspina,AS Brown,MA Perrin,H Chen,DE Sandberg,D Malaspina,AS Brown,

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Growth trajectory during early life and risk of adult schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The British journal of psychiatry : the journal of

VOLUME: 191

Page Numbers: 512-20

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ISSN: 0007-1250

DAY: 6

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Growth trajectory during early life and risk of adult schizophrenia.

AFFILIATION: The Cognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA. mperrin@nki.rfmh.org

Country: England

AGENCY: United States NICHD

GRANT: N01-HD-1-3334

ACRONYM: HD

MEDLINETA: Br J Psychiatry

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