Growth hormone treatment in Turner's syndrome.

Growth hormone treatment in Turner's syndrome. Research Abstract Details 

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Growth hormone treatment in Turner's syndrome. Abstract Text:

K Takano,N Hizuka,K Shizume,

A total of 21 patients with Turner's syndrome were treated with pituitary hGH and/or somatrem for 1-2 years. Plasma non-esterified fatty acid increased significantly from 0.52 +/- 0.06 to 1.30 +/- 0.09 mEq/litre at 4 hours after injection of hGH, 4 IU (mean +/- SEM, p less than 0.001). Basal plasma IGF-1 levels were within the normal range; however, they increased significantly at 24 hours after the first three daily injections of hGH, 4 IU (basal, 0.92 +/- 0.14 units/ml; 24 hours, 1.39 +/- 0.16 units/ml; 48 hours, 1.68 +/- 0.19 units/ml; 72 hours, 1.91 +/- 0.22 units/ml; p less than 0.001). For long-term treatment, patients were given hGH, 4-16 IU for 1-2 years. Their height velocity increased to 5.5 +/- 1.2 cm/year and 5.1 +/- 0.6 cm/year in the first and second year of the treatment, respectively. These values were greater than the pretreatment value of 3.6 +/- 0.8 cm/year (p less than 0.001). Antibody against hGH was observed in 60% of the patients at the end of 12 months of somatrem treatment. Otherwise there were no significant changes in physical, blood or urine examinations. These results indicate that hGH treatment is useful for the acceleration of growth velocity in patients with Turner's syndrome.

Growth hormone treatment in Turner's syndrome. Publishing Authors By Initials

K Takano,N Hizuka,K Shizume,

For similar male urogenital diseases: urogenital abnormalities: sex differentiation disorders: gonadal dysgenesis: turner syndrome research abstracts see: male urogenital diseases: urogenital abnormalities: sex differentiation disorders: gonadal dysgenesis: turner syndrome research

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Growth hormone treatment in Turner's syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta paediatrica Scandinavica. Supplement

VOLUME: 325

Page Numbers: 58-63

Journal Abbreviation:

ISSN: 0300-8843

DAY: 20

MONTH: 02

YEAR: 1986

Growth hormone treatment in Turner's syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 173166

Growth hormone treatment in Turner's syndrome. Keywords Mesh Terms:

KEYWORDS: Turner Syndrome

MESH TERMS: immunology

Chemical & Substance for Abstract: Growth hormone treatment in Turner's syndrome. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Growth hormone treatment in Turner's syndrome.

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Country: SWEDEN

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MEDLINETA: Acta Paediatr Scand Suppl

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• Growth hormone treatment in Turner's syndrome.
• Urinary IGF-I measurement and its clinical application.