Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression.

Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Research Abstract Details 

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Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Abstract Text:

Eva Szentirmai,Tadanobu Yasuda,Ping Taishi,Mingxiang Wang,Lynn Churchill,Stewart Bohnet,Paul Magrath, ,Lissette Jimenez,James M Krueger,

Growth hormone-releasing hormone (GHRH), its receptor (GHRHR), and other members of the somatotropic axis are involved in non-rapid eye movement sleep (NREMS) regulation. Previously, studies established the involvement of hypothalamic GHRHergic mechanisms in NREMS regulation, but cerebral cortical GHRH mechanisms in sleep regulation remained uninvestigated. Here, we show that unilateral application of low doses of GHRH to the surface of the rat somatosensory cortex ipsilaterally decreased EEG delta wave power, while higher doses enhanced delta power. These actions of GHRH on EEG delta wave power occurred during NREMS but not during rapid eye movement sleep. Further, the cortical forms of GHRH and GHRHR were identical to those found in the hypothalamus and pituitary, respectively. Cortical GHRHR mRNA and protein levels did not vary across the day-night cycle, whereas cortical GHRH mRNA increased with sleep deprivation. These results suggest that cortical GHRH and GHRHR have a role in the regulation of localized EEG delta power that is state dependent, as well as in their more classic hypothalamic role in NREMS regulation.

Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Publishing Authors By Initials

E Szentirmai,T Yasuda,P Taishi,M Wang,L Churchill,S Bohnet,P Magrath,B ,L Jimenez,JM Krueger,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: parietal lobe: somatosensory cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: parietal lobe: somatosensory cortex research

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Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Regulatory, integr

VOLUME: 293

Page Numbers: R922-30

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 30

MONTH: 05

YEAR: 2007

Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Keywords Mesh Terms:

KEYWORDS: Somatosensory Cortex

MESH TERMS: physiology

Chemical & Substance for Abstract: Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Information

Substance Name: Growth Hormone-Releasing Hormone

Registry Number: 9034-39-3

Grant and Affiliation Information for Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression.

AFFILIATION: Washington State University, College of Veterinary Medicine, Program in Neuroscience, Pullman, WA 99164-6520, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS27250

ACRONYM: NS

MEDLINETA: Am J Physiol Regul Integr Comp

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