Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study.

Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study. Research Abstract Details 

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Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study. Abstract Text:

The purpose of this pilot study was to investigate the metabolic effects of growth hormone (GH) (Humatrope, Eli Lilly & Co., Indianapolis, IN) administration in postoperative (PO) patients receiving peripheral vein nutrition. Seven, well-nourished, nondiabetic patients undergoing elective surgical procedures were given either no drug (n = 3), GH 30 micrograms/kg/day (n = 2), or GH 60 micrograms/kg/day (n = 2) sub-Q daily until eating, up to 7 days PO. All the patients received 5% dextrose with electrolytes in the first 24 hours PO and then received calories at 80 +/- 5% of the measured resting energy expenditure (REE) and amino acid at 1 g/kg/day with electrolytes, vitamins, and minerals. There were no significant outcome differences between the 30 and 60 micrograms/kg/day groups and, therefore, these groups were analyzed together (n = 4). By day 6 of the study, the GH group had a significant reduction in the respiratory quotient (RQ) measured by indirect calorimetry; an increase in nitrogen retention; an increase in plasma transferrin concentrations; and an increase in plasma insulinlike growth factor (IGF1) concentration. There was no increase in blood glucose concentrations, or decrease in urinary 3-methylhistidine excretion; and no adverse effects occurred. We concluded that GH in PO patients on hypocaloric nutrition promoted protein synthesis, fat oxidation, and nitrogen retention. Effective parenteral nutritional support in postoperative adult patients can be achieved without the use of central vein access.

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Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American College of Nutrition

VOLUME: 9

Page Numbers: 610-5

Journal Abbreviation: J Am Coll Nutr

ISSN: 0731-5724

DAY: 23

MONTH: Dec

YEAR: 1990

Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study. Information

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LANGUAGE: eng

NlmUniqueID: 8215879

Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study. Keywords Mesh Terms:

KEYWORDS: Transferrin

MESH TERMS: analysis

Chemical & Substance for Abstract: Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study.

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Country: UNITED STATES

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MEDLINETA: J Am Coll Nutr

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