Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system.

Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. Research Abstract Details 

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Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. Abstract Text:

L M Seoane,O Al-Massadi,F Barreiro,C Dieguez,F F Casanueva,L M Seoane,O Al-Massadi,F Barreiro,C Dieguez,F F Casanueva,

Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has recently been the focus of extensive study, the secretion mechanism is not yet well characterized. The aim of this study was to test the direct effect of hormones from the somatotropic axis on ghrelin release directly from the stomach. To this end, an organ culture model of gastric tissue explants from rat donors was used. These stomach explants were incubated in 6 well plates for 1, 2, and 3 h after treatment with either GH, GHRH, SS or IGF-I, all them at 10(-6) M. After incubation, the medium was collected and the amount of ghrelin secreted by the gastric tissue was measured by radioimmunoassay. It was observed that GH and SS significantly decreased gastric ghrelin secretion, while GHRH and IGF-1 had no effect on the present model. These results would confirm the capacity of GH and SS to act directly upon gastric level, inhibiting ghrelin secretion in vitro.

Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. Publishing Authors By Initials

LM Seoane,O Al-Massadi,F Barreiro,C Dieguez,FF Casanueva,LM Seoane,O Al-Massadi,F Barreiro,C Dieguez,FF Casanueva,

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Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of endocrinological investigation

VOLUME: 30

Page Numbers: RC22-5

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ISSN: 1720-8386

DAY: 12

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Molecular Endocrinology, Investigation Area, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), PO Box 563, E-15780, Santiago de Compostela, Spain. fssisisc@usc.es

Country: Italy

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MEDLINETA: J Endocrinol Invest

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